Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Vertical sleeve gastrectomy linked to higher postsurgery acute pancreatitis risk

12 Oct 2018

Vertical sleeve gastrectomy (VSG) confers a higher risk of acute pancreatitis (AP) than Roux-en-Y gastric bypass surgery (RYGB), particularly in young patients and in those with gallstones, reports a recent study.

Drawing from the National Readmission Database of the USA, researchers compared the rates of AP within 6 months before and after surgery among morbidly obese participants who underwent VSG (n=205,251), RYGB (169,973) or hernia repair (HR; controls; n=16,845). Each group was further divided into pre- and postsurgery cohorts, depending on the timing of patient discharge.

Presurgery AP was highest in the HR group (0.17 percent), while postsurgery AP was most prevalent in patients who received VSG (0.21 percent). More than half (58.3 percent) of AP readmission occurred within 30 days after VSG.

After complete adjustments for confounding variables such as age, sex and comorbidities, weighted logistic regression analysis showed that the risk of post- vs presurgery AP was highest in patients who received AP (adjusted odds ratio [OR], 5.16; 95 percent CI, 3.11–8.56; p<0.001).

The post- vs presurgery AP risk associated with RYGB was also significantly elevated, but to a lesser degree (adjusted OR, 2.26; 1.33–3.87; p=0.003). No increase in AP risk following HR was observed.

Moreover, when researchers compared the types of surgery with each other, they showed that VSG resulted in a significantly higher post- vs presurgery AP risk than RYGB (adjusted OR, 2.28; 1.10–4.73; p=0.03) and HR (adjusted OR, 7.58; 2.09–27.58; p=0.002). There was no significant difference between RYGB and HR (adjusted OR, 3.33; 0.91–12.18; p=0.07).

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, Yesterday
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.