Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.

Vedolizumab safe, effective against Crohn’s disease

10 Oct 2019
Crohn’s is not the end of the world, as Kathleen Baker’s silver medal proves

Vedolizumab induces endoscopic and histologic remission of Crohn’s disease (CD), a recent study has found.

Researchers prospectively assessed 110 patients (median age, 36 years; 77 percent female) with active CD who received 300 mg of open-label vedolizumab infusions. Ileocolonoscopies with biopsy collections were performed at baseline and at weeks 26 and 52 for the assessment of endoscopic and histologic outcomes. Treatments were given at weeks 0, 2 and 6, and every 8 weeks thereafter through week 52.

After 26 weeks of treatment, 40 percent (n=44) of the participants showed endoscopic response, while 33 percent (n=36) were positive for endoscopic remission. At 52 weeks, the corresponding rates climbed slightly to 45 percent (n=50) and 36 percent (n=40), respectively.

Results of the Simple Endoscopic Score for CD (SES-CD) changed by 4.05 and 4.65 points from baseline to weeks 26 and 52, respectively.

For the histologic analysis, a total of 132 paired biopsies in 65 patients were analysed. Sixty-seven biopsies were positive for inflammation at baseline, as measured by the Geboes score. Of these, 43 (64 percent) showed signs of remission by week 26.

In comparison, Robarts Histopathology Index-defined active inflammation at baseline was reported in 56 biopsies. After 26 weeks of treatment, 66 percent (n=37) of these samples had undergone histological remission.

Vedolizumab had a good safety profile. Only two serious adverse events were reported, and only three patients had to discontinue the treatment due to side effects. The most common adverse events were headaches, nasopharyngitis and skin-related problems.

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Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.