Most Read Articles
3 days ago
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting. 

Vedolizumab safe, effective against Crohn’s disease

10 Oct 2019
Crohn’s is not the end of the world, as Kathleen Baker’s silver medal proves

Vedolizumab induces endoscopic and histologic remission of Crohn’s disease (CD), a recent study has found.

Researchers prospectively assessed 110 patients (median age, 36 years; 77 percent female) with active CD who received 300 mg of open-label vedolizumab infusions. Ileocolonoscopies with biopsy collections were performed at baseline and at weeks 26 and 52 for the assessment of endoscopic and histologic outcomes. Treatments were given at weeks 0, 2 and 6, and every 8 weeks thereafter through week 52.

After 26 weeks of treatment, 40 percent (n=44) of the participants showed endoscopic response, while 33 percent (n=36) were positive for endoscopic remission. At 52 weeks, the corresponding rates climbed slightly to 45 percent (n=50) and 36 percent (n=40), respectively.

Results of the Simple Endoscopic Score for CD (SES-CD) changed by 4.05 and 4.65 points from baseline to weeks 26 and 52, respectively.

For the histologic analysis, a total of 132 paired biopsies in 65 patients were analysed. Sixty-seven biopsies were positive for inflammation at baseline, as measured by the Geboes score. Of these, 43 (64 percent) showed signs of remission by week 26.

In comparison, Robarts Histopathology Index-defined active inflammation at baseline was reported in 56 biopsies. After 26 weeks of treatment, 66 percent (n=37) of these samples had undergone histological remission.

Vedolizumab had a good safety profile. Only two serious adverse events were reported, and only three patients had to discontinue the treatment due to side effects. The most common adverse events were headaches, nasopharyngitis and skin-related problems.

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Most Read Articles
3 days ago
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting.