Most Read Articles
27 Nov 2017
The amino sulphonic acid taurine may safely and effectively reduce portal pressure in cirrhotic patients, a study has shown.
Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
Audrey Abella, 23 Jan 2019
A single infusion of the monoclonal antibody rituximab temporarily delays the clinical onset of rheumatoid arthritis (RA) through B-cell depletion, underpinning the preventive potential of rituximab in RA development especially in high-risk individuals, according to the PRAIRI* study.
26 Nov 2019
Podcast: Professor R. Scott Wright speaks about the potential role of inclisiran in providing durable reductions in LDL-cholesterol levels in patients with atherosclerotic cardiovascular disease.

Vedolizumab does not promote malignancies in IBD patients

08 Jan 2020

Use of vedolizumab for inflammatory bowel disease (IBD) does not contribute to an increased incidence of malignancies, with data from the GEMINI LTS study showing that the rate is similar in groups of patients who received the 4- and 8-weekly infusion regimens.

The current analysis included 1,785 IBD patients (mean age, 39.5 years; 49 percent female) with ≥1 year of follow-up after vedolizumab initiation. Of these, 1,034 had Crohn’s disease (CD) and 751 had ulcerative colitis (UC).  

In 5,670 patient‐years of included vedolizumab exposure, 31 patients (mean age, 51.2 years; 45 percent female) developed malignancies, including 17 with CD and 14 with UC.

Prior use of anti‐TNFα therapy in the group that developed malignancies was documented in 65 percent of CD patients and 57 percent of UC patients; the corresponding proportions in the LTS study were 62 percent and 43 percent.

Researchers indirectly standardized the number of patients experiencing malignancies in the LTS study against the number expected using age- and sex-specific rates in IBD patients from Optum's Clinformatics Data Mart (CDM) database and found that the numbers did not significantly differ (31 vs 29; ratio of observed to expected events, 1.08, 95 percent confidence interval [CI], 0.73–1.53; p=0.71). The most common sites of malignancies were renal and bladder (n=6), lower gastrointestinal (GI) tract (n=5), and respiratory tract (n=4).

In the postmarketing setting, 293 patients reported 299 malignancies (including malignancies within 1 year after vedolizumab initiation) in about 208,050 patient-years of vedolizumab exposure. Lower GI malignancies were most common (n=59).

Despite the presence of limitations, the existing data revealed no evidence of any significant increase in incidence of malignancy in patients with IBD receiving vedolizumab, the researchers said.

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Most Read Articles
27 Nov 2017
The amino sulphonic acid taurine may safely and effectively reduce portal pressure in cirrhotic patients, a study has shown.
Prof. Vincent Wong, Prof. Ray Kim, Dr. Tan Poh Seng, 10 Sep 2019
Chronic hepatitis B (CHB) remains a major public health concern because of its worldwide distribution and potential adverse sequelae, including cirrhosis and hepatocellular carcinoma (HCC). At a recent symposium held during the GIHep Singapore 2019, Professor Vincent Wong from the Chinese University of Hong Kong and Professor Ray Kim from the Stanford University School of Medicine, Stanford, California, US, discussed antiviral treatments for CHB, with a focus on the novel agent tenofovir alafenamide (Vemlidy®). Dr Tan Poh Seng from the National University Hospital, Singapore, chaired the symposium.
Audrey Abella, 23 Jan 2019
A single infusion of the monoclonal antibody rituximab temporarily delays the clinical onset of rheumatoid arthritis (RA) through B-cell depletion, underpinning the preventive potential of rituximab in RA development especially in high-risk individuals, according to the PRAIRI* study.
26 Nov 2019
Podcast: Professor R. Scott Wright speaks about the potential role of inclisiran in providing durable reductions in LDL-cholesterol levels in patients with atherosclerotic cardiovascular disease.