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10 Jan 2021
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
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Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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Vedolizumab, TNF blockers for IBD pose no new or recurrent cancer risk

19 Nov 2020

Among inflammatory bowel disease (IBD) patients with a current or prior malignancy, treatment with vedolizumab (VDZ) or antitumour necrosis factor (anti-TNF) does not bear an increased hazard of developing new or recurrent cancer, as shown in a study.

The analysis included 463 IBD patients, among whom 96 patients were exposed to VDZ (mean duration, 1.7 person-years) after a diagnosis of cancer and 184 to anti-TNF (mean duration, 3.6 person-years). Some 183 patients received no immunosuppression therapy.

Half of the overall population had solid tumours as the primary cancer. Over a median of 6.2 person-years of follow-up, cancer events occurred in 18 patients on VDZ (new, n=7; recurrent, n=11), 61 patients on anti-TNF (new, n=27; recurrent, n=34), and 78 controls (new, n=30; recurrent, n=48). The corresponding incidence rates were 2.2, 4.2, and 5.6 per 1,000 person-years.

Multivariable Cox analysis revealed that the risk of developing new or recurrent cancer did not increase following exposure to VDZ (hazard ratio [HR], 1.38, 95 percent confidence interval [CI], 0.38–1.36) or anti-TNF therapy (HR, 1.03, 95 percent CI, 0.65–1.64) relative to no immunosuppression.

Analysis by biologic exposure time yielded similar results. Compared with anti-TNF, VDZ did not confer a risk increase in cancer events (HR, 0.82, 95 percent CI, 0.45–1.49).

The findings provide reassurance regarding the use of VDZ in the present population, as well as provide further evidence of the safety of anti-TNF therapy.

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Most Read Articles
10 Jan 2021
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.