Most Read Articles
Roshini Claire Anthony, Yesterday

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
17 May 2018
A study examining the validity of baseline cardiac screening for left ventricular ejection fraction (EF) has found that only two (1.1 percent) of the screened patients have an abnormal EF (<50 percent). These patients have received doxorubicin (anthracycline) chemotherapy despite a compromised EF.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

VCE, CTE both useful in diagnosis of small bowel bleeding

31 Jul 2017

Both video capsule endoscopy (VCE) and computed tomography enterography (CTE) complement each other in the diagnosis of potential small bowel (SB) bleeding, suggests a recent study. Clinicians should consider CTE when VCE is negative.

In addition, severe bleeding and age <40 years independently predict a higher diagnostic yield for CTE, according to researchers.

In this study that compared the efficacy of VCE with CTE and identified factors predictive of a high diagnostic yield for CTE, the authors prospectively enrolled consecutive patients with potential SB bleeding. Participants underwent VCE and CTE within a 1-week interval.

Surgery or enteroscopy was utilized to achieve definitive diagnoses, except when a strategy of VCE and conservative management was suitable. Researchers then measured diagnostic yields and sensitivities of each investigation.

Of the 52 patients (41 with overt and 11 with occult bleeding) recruited in the study, 36 received a definitive diagnosis. The corresponding diagnostic yields and sensitivities were 59.6 and 30.8 percent (p=0.004) for VCE, and 72.2 and 44.4 percent (p=0.052) for CTE.

The combined sensitivity of VCE and CTE was 88.9 percent, which is significantly greater than VCE (p=0.03) or CTE (p<0.01) alone. VCE was better for ulcers, enteritis and angiodysplasia, while CTE was better for tumours and Meckel diverticula.

Age <40 years (odds ratio [OR], 7.3; 95 percent CI, 1.04 to 51.4; p=0.046) and severe bleeding (OR, 6.1; 1.4 to 25.5; p=0.014) were independent predictors of a higher diagnostic yield for CTE.

“In potential SB bleeding, CTE potentially detects some lesions missed by VCE, but few data have determined its clinical utility,” according to researchers.

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Most Read Articles
Roshini Claire Anthony, Yesterday

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
17 May 2018
A study examining the validity of baseline cardiac screening for left ventricular ejection fraction (EF) has found that only two (1.1 percent) of the screened patients have an abnormal EF (<50 percent). These patients have received doxorubicin (anthracycline) chemotherapy despite a compromised EF.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.