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Varying concentrations of alcohol do not alter pharmacokinetics of amphetamine

31 Aug 2017

Alcohol concentrations of between 4 and 40 percent appear to have no significant effect on the pharmacokinetic profile of the psychostimulant amphetamine, a study has found.

The phase I single-dose, open-label study included 32 healthy adults. Participants were randomized to receive amphetamine extended-release orally disintegrating tablet (AMP XR-ODT; 18.8 mg) in one of four sequences: following 240 mL of deionized water or 4, 20 or 40 percent ethanol. Blood samples were collected, and the pharmacokinetic profiles of d- and l-AMP were compared across treatment groups.

No change was seen in the extent of absorption for d- or l-AMP with alcohol coingestion. Moreover, there was no dose-dumping of the extended-release portion of the drug formulation.

The 90 percent CIs for the geometric mean ratios for Cmax (peak serum concentration the drug achieves in a specified test area of the body) and systemic exposure (area under the curve [AUC0]–5, AUClast and AUC0–∞) were in the range of 80 to 125 percent.

Adverse events were mild to moderate in severity, consistent with the known adverse event profile for AMP XR-ODT or alcohol.

The present data are relevant to clinicians who have concerns about alcohol use and/or abuse when treating attention deficit hyperactivity disorder (ADHD), researchers said.

Characterized by inattention, impulsivity and hyperactivity, ADHD can lead to alcohol and other drug (AOD)-related problems. In previous studies, it was shown that the mental disorder contributes to the development of AOD use disorders. The potential role of ADHD in the development of AOD use problems is said to have important implications for prevention and treatment of such problems. [Alcohol Res Health 2002;26:122-129]

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Most Read Articles
Saras Ramiya, 15 Apr 2017
After being introduced to Malaysia 10 years ago, Bio-Oil has established itself as a staple skincare brand.
Jenny Ng, 05 Aug 2015
Concerns emerge over combining antidepressants with non-steroidal anti-inflammatory drugs (NSAIDs) as a study shows an increased risk of intracranial haemorrhage (ICH) in these patients. 
Debra Kennedy, 01 Jun 2014

Pregnant women do not need to suffer unnecessary pain or potentially dangerous fever for fear of their taking medications that may be harmful to their unborn baby. Healthcare providers should be confident when prescribing appropriate treatment to such women during pregnancy.

Harriet Pugsley, MB ChB, MRCOG; Judith Moore, MRCOG, 01 Aug 2013

Most women presenting with complications in early pregnancy are assessed, diagnosed and managed at early pregnancy assessment units (EPAUs). These units aim to provide thorough assessments, access to specialist investigations (scan, human chorionic gonadotrophin [hCG]), a rapid turnaround of results, and co-ordination of further management.