Most Read Articles
Elvira Manzano, 2 days ago
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, 3 days ago
For individuals with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
In patients with type 2 diabetes (T2D), postprandial hyperglycaemia and hypertriglyceridemia worsens survival outlook, finds a new study.

Variability in gamma-glutamyl transferase levels linked to ESRD risk

05 Aug 2020

Variability in the levels of gamma-glutamyl transferase (GGT) appears to predict the development of end-stage renal disease (ESRD), reports a recent Korean study.

Researchers conducted a nation-wide, population-based study including 6,058,995 individuals. Variability in GGT was assessed using the average successive variability (ASV), standard deviation (SD), and coefficient of variation (CV) of serial GGT measurements. A diagnosis of ESRD, defined as kidney transplantation or initiating renal replacement therapy, was the primary outcome.

Over 38,663,279.3 person-years of follow-up, 12,077 of the enrolled participants developed ESRD, yielding an overall rate of 0.2 percent.

Analysis according to GGT quartile at baseline showed that ESRD was significantly more likely to occur in patients in the topmost quartile (hazard ratio [HR], 1.15, 95 percent confidence interval [CI], 1.09–1.21; ptrend<0.001). Similarly, those in the highest quartile of GGT ASV saw a significant spike in the risk of ESRD (HR, 1.12, 95 percent CI, 1.06–1.18; ptrend<0.001).

These results were largely robust to subgroup analyses. GGT ASV remained significantly indicative of ESRD risk in most models, except in patients who were of low income, who drank alcohol, and who had baseline estimated glomerular filtration rate <90 mL/min/1.73 m2.

Notably, the researchers reported similar and significant links between ESRD risk and GGT variability expressed as SD or CV.

“To our knowledge, this is the first study to investigate the relationship between GGT variability and the development of ESRD in a large general population,” the researchers said. “Because the serum GGT level is already a component of liver function tests routinely used with low cost, we expect that serial GGT measurements will be a meaningful predictor of ESRD risk.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elvira Manzano, 2 days ago
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, 3 days ago
For individuals with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
In patients with type 2 diabetes (T2D), postprandial hyperglycaemia and hypertriglyceridemia worsens survival outlook, finds a new study.