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Validated sonographic enthesitis instruments in PsA lacking

10 Jan 2019

Only a few sonographic enthesitis scoring instruments developed for spondyloarthritis (SpA) have been validated in psoriatic arthritis (PsA), and none of them passed the Outcome Measures in Rheumatology (OMERACT) filter in patients with PsA, according to a systematic review.

Of the 310 identified manuscripts, 51 were included. There was only one scoring instrument of enthesitis that was specifically developed and validated in patients with PsA.

Eighteen (35 percent) studies included patients with PsA, while others focused on SpA. In PsA, biomarkers and clinical examination were used to assess construct validity in one (2 percent) and 11 (21.5 percent) of the studies, respectively; none of the studies used imaging for the same purpose.

Of the studies, only two (4 percent) evaluated discriminative validity in PsA. Seven studies assessed responsiveness to treatment, none of which included patients with PsA.

“Additional research is required before endorsing a specific instrument for the assessment of enthesitis in patients with PsA,” the authors said.

As part of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) ultrasound working group, the authors searched PubMed, Embase and Cochrane databases for original publications containing terms related to ultrasound, enthesitis, SpA or PsA.

Data extraction focused on the properties of the sonographic enthesitis instruments used in each study following components of the OMERACT filter: feasibility, test-retest reliability, construct validity as related to clinical assessment of enthesitis, biomarkers of inflammation and imaging of enthesitis by other modalities, discriminative validity, and responsiveness to treatment.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
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There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.