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Validated sonographic enthesitis instruments in PsA lacking

10 Jan 2019

Only a few sonographic enthesitis scoring instruments developed for spondyloarthritis (SpA) have been validated in psoriatic arthritis (PsA), and none of them passed the Outcome Measures in Rheumatology (OMERACT) filter in patients with PsA, according to a systematic review.

Of the 310 identified manuscripts, 51 were included. There was only one scoring instrument of enthesitis that was specifically developed and validated in patients with PsA.

Eighteen (35 percent) studies included patients with PsA, while others focused on SpA. In PsA, biomarkers and clinical examination were used to assess construct validity in one (2 percent) and 11 (21.5 percent) of the studies, respectively; none of the studies used imaging for the same purpose.

Of the studies, only two (4 percent) evaluated discriminative validity in PsA. Seven studies assessed responsiveness to treatment, none of which included patients with PsA.

“Additional research is required before endorsing a specific instrument for the assessment of enthesitis in patients with PsA,” the authors said.

As part of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) ultrasound working group, the authors searched PubMed, Embase and Cochrane databases for original publications containing terms related to ultrasound, enthesitis, SpA or PsA.

Data extraction focused on the properties of the sonographic enthesitis instruments used in each study following components of the OMERACT filter: feasibility, test-retest reliability, construct validity as related to clinical assessment of enthesitis, biomarkers of inflammation and imaging of enthesitis by other modalities, discriminative validity, and responsiveness to treatment.

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Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.