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22 Nov 2020
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Vaginal atrophy treatment: Initiation at any age is fine, study says

14 Nov 2020

There is no best time to initiate low-dose vaginal oestrogen therapy (ET), since it improves the signs and symptoms of vaginal atrophy in both younger and older women, according to a posthoc analysis.

Data came from 198 postmenopausal women aged ≥45 years treated with 10-μg vaginal ET for 52 weeks. Outcomes were evaluated and compared between women aged <60 (n=143) and ≥60 years (n=55) at treatment initiation. Covariance analysis was applied.

Results for vaginal maturation index (for all cell layers; assessed by vaginal cytology samples), vaginal pH, and symptom scores were all encouraging in both age groups.

However, a significant between-group difference in cytological profiles (parabasal cells: estimated effect, –3.7; p=0.0003; intermediate cells: estimated effect, 5.8; p=0.0002) emerged. This was an indication that cellular responsiveness to treatment was less favourable among older women.

Specifically, the treatment effect on vaginal pH was less in the older age group, with a between-group difference of –0.19 (standard error, 0.05; p=0.0003).

While the findings suggest that treatment may be initiated at any age, the stronger response observed in younger women supports current clinical recommendations to start treatment early.

More importantly, treatment must be maintained to prevent recurrence of vaginal atrophy.

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Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.