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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Ustekinumab shows potential therapeutic benefit in perianal Crohn's Disease

22 Nov 2020

Use of ustekinumab appears effective in the treatment of perianal refractory Crohn’s disease (pCD), suggests a recent study.

A national multicentre retrospective cohort study was carried out involving patients with either active or inactive pCD who received ustekinumab. In patients with active pCD at treatment initiation, the success of ustekinumab was defined by clinical success at 6 months assessed by the physician’s judgment without additional medical or surgical treatment for pCD.

The authors performed univariate and multivariate logistic regression analyses to identify predictors of success. They also calculated the pCD recurrence-free survival in patients with inactive pCD at ustekinumab initiation using the Kaplan-Meier method.

In total, 207 patients (mean age, 37.7 years) were analysed. Participants had a mean CD duration of 14.3 years and mean number of prior perianal surgeries of 2.8. Of the patients, 205 (99 percent) had been previously exposed to at least one antitumour necrosis factor (anti-TNF) and 58 (28 percent) to vedolizumab. Median follow-up time was 48 weeks.

Fifty-six (27 percent) patients discontinued therapy after a median time of 43 weeks. Fifty-seven of 148 (38.5 percent) patients with active pCD achieved success. Among those with setons at initiation, 29 of 88 (33 percent) had a successful removal. Treatment success correlated with the absence of optimization (odds ratio [OR], 2.74, 95 percent confidence interval [CI], 0.96–7.82; p=0.044).

Multivariable analysis revealed that the number of prior anti-TNF (3) was borderline significant (OR, 0.4, 95 percent CI, 0.15–1.08; p=0.056).

Additionally, the odds of recurrence-free survival in patients with inactive pCD at initiation was 86.2 percent at week 26 and 75.1 percent at week 52.

“Further prospective studies are warranted,” the authors said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.