Most Read Articles
Stephen Padilla, 23 hours ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 3 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
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Using sex steroids may increase lumbar spine BMD in male-to-female transgenders

04 Dec 2017
Doctors and therapists are said to be failing transgender patients due to their lack of knowledge and expertise in the area.

The use of masculinizing hormone therapy in female-to-male (FTM) transgenders is not likely to lead to significant changes in bone mineral density (BMD), but in male-to-female (MTF) individuals, the use of feminizing hormone therapy may result in an increase in BMD at the lumbar spine, a recent study has found.

“The impact of these BMD changes on patient-important outcomes such as fracture risk is uncertain,” according to researchers.

Several databases were comprehensively searched through 7 April 2015 for studies assessing bone health in transgender individuals receiving sex steroids. Studies were selected and appraised by pairs of reviewers. Finally, researchers pooled weighted mean differences and 95 percent confidence intervals (CIs) using a random effects model.

A total of 13 studies involving 639 transgender individuals (392 MTF and 247 FTM) were included in the analysis. The body of evidence was obtained mostly from observational studies with a moderate risk of bias.

Compared with baseline values before initiation of masculinizing hormone therapy, 12- and 24-month assessment data showed that FTM individuals had no statistically significant difference in the lumbar spine, femoral neck or total hip bone BMD.

On the other hand, MTF individuals had a statistically significant increase in lumbar spine BMD at 12 months (0.04 g/cm2; 95 percent CI, 0.03 to 0.06 g/cm2) and 24 months (0.06 g/cm2; 0.04 to 0.08 g/cm2) when compared with baseline values before they started using feminizing hormone therapy.

No events were reported at 12 months following the assessment of fracture rates in a single cohort of 53 MTF and 53 FTM individuals.

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Most Read Articles
Stephen Padilla, 23 hours ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 3 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
15 Jun 2018
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.