Ursodeoxycholic acid linked to reduced carotid intima media thickness in NASH
UDCA, which purportedly has antioxidant, anti-inflammatory and hepatoprotective properties, was given to nonhypertensive, nondiabetic, normolipidaemic subjects with biopsy-proven NASH and healthy controls at 15 mg/kg/day for 6 months, to evaluate changes in BMI, waist circumference, homeostasis model assessment, lipids, apo A1, apo B, apo B/A1 ratios, and CIMT. Liver enzymes and the homeostasis model assessment, and Apo B/A1 ratios decreased; high-density lipoprotein (HDL) and apo A1 increased significantly. The mean CIMT decreased significantly. No statistically significant changes were noted in the other parameters.
The authors said the benefit of UDCA is due to decreased insulin resistance and increased HDL and apo A1 levels, but further studies are needed to confirm this.