Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
31 May 2017
New drug applications approved by US FDA as of 16 - 31 May 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
09 Dec 2017
Intravenous (IV) iron is less toxic and more effective compared to oral iron, making it a potential frontline therapy for neonatal iron deficiency anaemia, suggests a recent study.

Ursodeoxycholic acid linked to reduced carotid intima media thickness in NASH

10 Feb 2016
Non-alcoholic steatohepatitis (NASH) patients treated with ursodeoxycholic acid (UDCA) were shown to have reduced mean carotid intima media thickness (CIMT) in a prospective study.

UDCA, which purportedly has antioxidant, anti-inflammatory and hepatoprotective properties, was given to nonhypertensive, nondiabetic, normolipidaemic subjects with biopsy-proven NASH and healthy controls at 15 mg/kg/day for 6 months, to evaluate changes in BMI, waist circumference, homeostasis model assessment, lipids, apo A1, apo B, apo B/A1 ratios, and CIMT. Liver enzymes and the homeostasis model assessment, and Apo B/A1 ratios decreased; high-density lipoprotein (HDL) and apo A1 increased significantly. The mean CIMT decreased significantly. No statistically significant changes were noted in the other parameters.

The authors said the benefit of UDCA is due to decreased insulin resistance and increased HDL and apo A1 levels, but further studies are needed to confirm this.
Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Rachel Soon, 26 Jun 2018

MIMS Pharmacist presents an overview of phosphatidylcholine's physiological role, as well as contemporary research on its pharmacology and effects.

17 Mar 2018
Nonvitamin K antagonist oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) and vitamin K antagonists-ICH appear to have similar ICH volume, haematoma expansion, functional outcome and mortality, results of a recent meta-analysis have shown.
31 May 2017
New drug applications approved by US FDA as of 16 - 31 May 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
09 Dec 2017
Intravenous (IV) iron is less toxic and more effective compared to oral iron, making it a potential frontline therapy for neonatal iron deficiency anaemia, suggests a recent study.