Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
6 days ago
Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.

Urea breath test yields accurate results for H. pylori detection in Asian patients

22 Aug 2019

The carbon 13 urea breath test (13C-UBT) is sensitive and accurate for the diagnosis of Helicobacter pylori infection in Asians, as shown in the results of a systematic review and meta-analysis.

Researchers searched multiple online databases for studies evaluating the 13C-UBT diagnostic accuracy for H. pylori infection in an Asian population. They assessed for quality using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. 

The meta-analysis included 15 study protocols extracted from 11 articles. There was considerable bias noted for six articles in the domain of index test. On the other hand, two articles had unclear risk of bias for patient selection, which was based on an established condition or disease (partial gastrectomy patients and nonulcer dyspepsia patients).

Six of the studies were conducted in Hong Kong, five in Taiwan, two in Japan, and one each in Singapore and Israel. All studies had utilized histology as part of its gold standard of reference. Samples in all but one study comprised adults.

Pooled data revealed that 13C-UBT had sensitivity of 97 percent (95 percent CI, 96–98) and specificity of 96 percent (95–97) for diagnosing H. pylori infection, with significant heterogeneity between studies. Accuracy estimates further improved and heterogeneity significantly reduced after adjusting for the dose (50 mg) and breath sample collection time (20 minutes).

The present data support the test-and-treat strategy for H. pylori infection management, according to the researchers. Additional prevalence and cost-effectiveness studies are needed before this strategy can be adopted into national policy.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
6 days ago
Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.