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Upcoming expiratory pressure device may help reduce infection in cystic fibrosis

Roshini Claire Anthony
17 Jan 2017

An upcoming disposable positive expiratory pressure (PEP) device for individuals with cystic fibrosis may lessen the occurrence of infections and subsequently, reduce antibiotic use and medical consultations, said researchers from the University of Limerick, Ireland.

“[The new PEP device, SoloPEP] provides the same therapeutic effect as existing devices but eliminates the risk of infection because it is not used repeatedly over a long period of time and does not require cleaning,” said Professor Colum Dunne, Foundation Chair and Director of Research at the University of Limerick’s Graduate Entry Medical School, and co-principal investigator of the device.

Patients requiring PEP devices are taught how to use and clean the devices, and if proper cleaning instructions are not followed, the devices can become contaminated with bacteria, said Dunne.

“Noncompliance with cleaning happens as patients do not see it as necessary, they forget, or they simply do not have the time. The net effect is that patients who have presented with infections can be treated successfully with antibiotics, only to have the same infection recur as they breathe in the same problematic bacteria from their own poorly cleaned devices,” he said, noting that the new device will eliminate this risk.

According to Dunne, SoloPEP is an innovation involving a novel engineering mechanism that as per currently available PEP devices, “involves the patient exhaling against a fixed-orifice resistor or a threshold resistor, generating preset pressures”, an action which helps dislodge trapped mucus secretions and moves them towards larger airways to enable expulsion. [Hippokratia 2008;12:211-220] However, the SoloPEP device is smaller and due to its disposability, does not require cleaning, thus improving convenience, said Dunne.

Behind the development of the product is a multidisciplinary team including microbiologists, medical device engineers, and respiratory physicians who treat both adult and paediatric respiratory illness. Creation of this device was a multistep process which involved auditing bacterial outbreaks and detecting previously undetected bacteria in the nasal sinuses, said Dunne. The researchers also observed patients’ practices and discussed with them the challenges faced in using PEP devices.  

“This is a prime example of where patients and their carers provided the stimulus for innovation,” said Dunne. Products such as ours will help reduce antimicrobial use, reduce hospital stays, reduce numbers presenting at GPs and emergency rooms, and improve at-risk patients’ quality of life overall,” said Dunne.

The University of Limerick has recently received funding to develop the device which is expected to be on the market within 2 years and will be suitable for both adults and children.

From L-R: Prof Deirdre McGrath (respiratory consultant), Prof Colum Dunne (director of research), and Dr Leonard O' Sullivan (senior lecturer, design ergonomics)

From L-R: Prof Deirdre McGrath (respiratory consultant), Prof Colum Dunne (director of research), and Dr Leonard O' Sullivan (senior lecturer, design ergonomics)

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Most Read Articles
Dr. Joseph Delano Fule Robles, 5 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

01 Aug 2017
New drug applications approved by US FDA as of 1 - 15 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
27 May 2016
TRIPLIXAM – Perindopril arginine, Indapamide, Amlodipine FC tab – Servier
01 Jul 2016
Get access to disease management charts, dosage guidelines and much more.