Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Universal influenza vaccine one step closer to reality

18 Apr 2020

Adjuvanted FLU-v, a broad-spectrum influenza vaccine that induces antibodies and cell-mediate immunity, has demonstrated immunogenicity in a phase IIb trial, warranting phase III development to explore its safety and efficacy.

This randomized, double-blind, placebo-controlled, single-centre clinical trial randomly assigned 175 healthy adults aged 18–60 years to 0.5-mL subcutaneous infection of 500 µg of adjuvanted (one dose) or nonadjuvanted (two doses) FLU-v (A-FLU-v or NA-FLU-v) or adjuvanted or nonadjuvanted placebo (A-placebo or NA-placebo).

The investigators used flow cytometry and enzyme-linked immunosorbent assay to assess vaccine-specific cellular responses at days 0, 42 and 180. They also collected solicited information on adverse events (AEs) for 21 days after vaccination and unsolicited information on AEs throughout the study.

Mild-to-moderate injection site reactions were the most common AEs. The difference in median fold increase in secreted interferon-γ (IFN-γ) between A-FLU-v and A-placebo was 38.2-fold (95 percent confidence interval [CI], 4.7–69.7; p=0.001) at day 42 and 25.0-fold (95 percent CI, 5.7–50.9; p<0.001) at day 180.

At day 42, differences in median fold increase between A-FLU-v and A-placebo were 4.5-fold (95 percent CI, 2.3–9.8; p<0.001) for IFN-γ–producing CD4+ T cells, 4.9-fold (95 percent CI, 1.3–40.0; p<0.001) for tumour necrosis factor-α (TNF-α), 7.0-fold (95 percent CI, 3.5–18.0; p<0.001) for interleukin-2 (IL-2), and 1.7-fold (95 percent CI, 0.1–4.0; p=0.004) for CD107a.

At day 180, differences were 2.1-fold (95 percent CI, 0.0–6.0; p=0.030) for IFN-γ and 5.7-fold (95 percent CI, 2.0–15.0; p<0.001) for IL-2, with no difference for TNF-α or CD107a.

There were no differences observed between NA-FLU-v and NA-placebo.

“The study was not powered to evaluate vaccine efficacy against influenza infection,” the investigators noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.