Most Read Articles
Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 12 hours ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.

Undiagnosed prediabetes may weaken PDE5i efficacy against erectile dysfunction

19 Jul 2020
Erectile dysfunction was found to be strongly associated with vascular endothelial dysfunction.

Phosphodiesterase type 5 inhibitors (PDE5is) have weaker efficacy in erectile dysfunction (ED) patients with undiagnosed pre-diabetes (PreDM), a recent study has shown.

Researchers enrolled 466 men with ED, who were made to accomplish the International Index of Erectile Function (IIEF) at baseline and after 3 months of PDE5i treatment. PreDM status was identified according to the criteria set by the American Diabetes Association. The outcome was the effect of PreDM on treatment response, evaluated according to the minimal clinically important difference (MCID).

Most (56.7 percent; n=253) of the participants were normoglycaemic, while 23.5 percent (n=105) and 19.7 percent (n=88) had PreDM and DM, respectively. Those in the latter two groups tended to be older, have higher body mass index, and have more comorbid conditions than the normoglycaemic controls (p<0.001 for all).

At baseline, scores in the erectile function domain of the IIEF (IIEF-EF) were lower in both the DM (p<0.001) and preDM (p=0.02) groups relative to controls. Severe ED was likewise more common in both diabetes subgroups.

PDE5i treatment resulted in significant clinical improvement in all groups, yielding mean change values in IIEF-EF scores that were all positive and statistically significant. At the 3-month follow-up, however, the researchers documented significantly higher IIEF-EF scores in controls than in both PreDM and DM groups (26.0 vs 20.0 and 17.5; p<0.001). Similarly, significant MCID improvements were more common in normoglycaemic controls (65.3 percent vs 22.9 percent and 11.8 percent; p<0.01).

Multivariable analysis confirmed that DM (odds ratio [OR], 0.37; p=0.02) and a lower IIEF-EF at baseline (OR, 0.94; p<0.001) were correlated with MCID response to PDE5i. Interestingly, no such link was found for PreDM (OR, 0.78; p=0.43).

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Most Read Articles
Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 12 hours ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.