Most Read Articles
4 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
6 days ago
Atrial fibrillation (AF) carries an excess risk of stroke recurrence independent of comorbidity with and heart failure (HF), while HF without AF also poses a significant risk of recurrence, a study has shown.
Roshini Claire Anthony, 3 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.

Undiagnosed peripheral artery disease common among high-risk patients

19 May 2019

Undiagnosed peripheral arterial disease (PAD) is common among high-risk patients, reports a new Australia study.

Drawing from the Australian Reduction of Atherothrombosis for Continued Health Registry, researchers identified 2,489 patients (mean age, 72.8±8.8 years; 65.3 percent male) who were at high risk of atherothrombosis. Only those without prior PAD diagnoses and had an ankle-brachial index (ABI) <1.4 at recruitment were eligible.

Of the participants, 34 percent were positive for PAD, with around 28 percent having low ABI (ABI+’; ABI<0.9) and 11 percent having intermittent claudication (IC). Overall, the rates of all-cause mortality and PAD events in the overall cohort were low, at 2 percent and 1.2 percent, respectively.

Disaggregation showed that all-cause mortality (2.9 percent vs 1.6 percent) and PAD events (2.1 percent vs 0.9 percent) occurred more commonly in ABI+ patients. IC patients, on the other hand, were more likely to experience nonfatal events (11.8 percent vs 8.3 percent) and PAD events (4.8 percent vs 0.8 percent). Moreover, Cox regression analysis found that PAD events were more likely to occur in patients who were positive for IC, regardless of whether IC was normal or low.

One-year follow-up data was available for 2,013 patients, of whom 123 (6 percent) developed IC. In this group, the risk of IC was 1.6-times higher in participants with low ABI as compared with those who had normal ABI values.

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Most Read Articles
4 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
6 days ago
Atrial fibrillation (AF) carries an excess risk of stroke recurrence independent of comorbidity with and heart failure (HF), while HF without AF also poses a significant risk of recurrence, a study has shown.
Roshini Claire Anthony, 3 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.