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Uncontrolled hypertension likely to have retinal vessel equivalents outside reference range

20 Jul 2017

Untreated or insufficiently treated hypertension is associated with retinal vessel equivalents outside the reference range, according to a recent study, which provides sex- and age-specific normative data for retinal vasculature.

Researchers assessed the fundus photographs from 4,309 participants of the Gutenberg Health Study using the retinal vessel analyser software (IMEDOS) to generate normative data for retinal vessel parameters and to evaluate the clinical relevance in systemic hypertension.

Sex- and age-specific nomograms in a disease-free subpopulation of 890 participants were generated to determine the central retinal arteriolar equivalent (CRAE), the central retinal venular equivalent and the arteriovenous ratio (AVR).

CRAE, AVR and central retinal venular equivalent values were greater in women than in men, and the decrease in measures with increasing age was less steep in women than in men.

Systemic hypertension correlated with lower values of AVR (men: odds ratio [OR], 2.41; 95 percent CI, 1.669 to 3.490; p<0.001; women: OR, 3.01; 2.126 to 4.268; p<0.001) and CRAE (men: OR, 2.60; 1.563 to 4.326; p<0.001; women: OR, 3.00; 2.004 to 4.487; p<0.001).

Participants with uncontrolled hypertension had lower median CRAE (172.28; range, 83.05 to 251.04) and AVR (0.81; 0.56 to 1.04) compared with those with screening-detected hypertension (CRAE, 175.72; 101.23 to 222.09; p<0.001; AVR, 0.82; 0.64 to 1.05; p=0.001) and those with controlled hypertension (CRAE, 179.10; 108.19 to 221.92; p<0.001; AVR, 0.84; 0.60 to 1.08; p<0.001).

“In-vivo measurement of retinal vascular calibers may be used as a tool to study the pathophysiology and clinical status of the microvasculature of the retina,” researchers said.

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Most Read Articles
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
6 days ago
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15 Jun 2018
New drug applications approved by US FDA as of 1 - 15 June 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Pearl Toh, 6 days ago
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