Most Read Articles
Elvira Manzano, 13 Apr 2020
A gout drug that’s been around for years reduced the risk of ischaemic cardiovascular (CV) events when given at a low dose in patients who had myocardial infarction (MI) and was cost-effective, an analysis of the COLCOT* trial has shown.
Christina Lau, 02 Jan 2020

Tolvaptan improves dyspnoea, increases sodium levels and reduces body weight in patients with acute heart failure (HF) with or without hyponatraemia, but no significant effect is seen in mortality or rehospitalization, according to a recent meta-analysis.

Pearl Toh, 15 Apr 2020
Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis who are at low surgical risk appears to be safe with low rates of death or disabling stroke at 30 days, according to a study presented at the ACC.20/WCC Virtual Meeting.

Uncontrollable high BP reduction may heighten risk for chronic pain in hypertensive patients

17 Apr 2020
29 sources of inaccuracy have been identified in the measurement of adults’ resting blood pressure in clinical settings.

Hypertensive patients with uncontrollable reduction of high blood pressure (BP) are at increased risk for chronic pain incidence and severity, a study has shown. Practical recommendations in BP control are thus needed in consideration of the patients’ chronic pain.

The authors conducted a narrative review of respective studies with analysis of credibility of the findings. In some studies, aggressive reduction of high BP was associated with a return in pain symptoms, which may require more aggressive, long-term pain management.

Other studies suggested that long-term antihypertensive treatment could also elevate the risk for new cases of chronic pain.

“Pain initiates a central neuroplastic resetting of the baroreceptor activation accounting for sustained increase of BP with an adaptive ‘pain-killing’ or maladaptive ‘pain-complication’ effect associated with pain chronification,” the authors explained, adding that antihypertensive drugs could moderate such mechanisms.

However, certain antihypertensive medications and nondrug treatment might have different effects on pain mechanisms at various stages of treatments.

More research is thus warranted on the moderation effects of different antihypertensive manipulations on pain to improve the management of pain in patients with hypertension, according to the authors.

“Although progress has been made in the regulation of hypertension over the past decades, the US and some other countries have faced a significant rise in incidence of chronic pain management cases during the same period,” the authors noted.

“Studies of the relationship between pain and BP regulations propose that these two processes may be interconnected,” they added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elvira Manzano, 13 Apr 2020
A gout drug that’s been around for years reduced the risk of ischaemic cardiovascular (CV) events when given at a low dose in patients who had myocardial infarction (MI) and was cost-effective, an analysis of the COLCOT* trial has shown.
Christina Lau, 02 Jan 2020

Tolvaptan improves dyspnoea, increases sodium levels and reduces body weight in patients with acute heart failure (HF) with or without hyponatraemia, but no significant effect is seen in mortality or rehospitalization, according to a recent meta-analysis.

Pearl Toh, 15 Apr 2020
Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic stenosis who are at low surgical risk appears to be safe with low rates of death or disabling stroke at 30 days, according to a study presented at the ACC.20/WCC Virtual Meeting.