Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.

Ultrasound useful for monitoring crystal dissolution in gout under urate-lowering therapy

03 Nov 2018

Ultrasound accurately shows the disappearance of urate disposition in gout patients undergoing urate-lowering therapy (ULT), according to the results of the USEFUL study.

Researchers followed for 6 months 79 gout patients (mean age 61.8 years; 91 percent male; mean disease duration 6.3 years) showing ultrasound features of tophus and/or double contour sign at the knee and/or first metatarsophalangeal joints. All patients started ULT.

Evaluations were performed at baseline and at months 3 and 6 following treatment. Outcomes investigated included the change in features of gout at month 6 and the final serum urate (SU) level (high, >360 μmol/L; low, 300–360 μmol/L; very low, <300 μmol/L).

At baseline, mean serum urate (SU) level was 530 µmol/L. A total of 74 patients (94 percent) had 1 ultrasound tophus, while 68 (86 percent) had double contour sign.

At month 6, among the 67 patients who completed the study, 18 and 39 patients achieved very low and low SU levels, respectively. Ultrasound features of gout decreased significantly in the lowest SU level group (p<0.001).

Final SU level at month 6 positively correlated with decreased tophus size (p<0.0001) and inversely correlated with proportion of double contour sign disappearance (p<0.0001).

USEFUL confirms that ultrasound allows for visualization of monosodium urate crystal deposits clearance under efficient ULT, as well as suggest that a reduction in SU level correlates with a decrease in ultrasound features of gout, researchers said.

In the era of targeted treatment, ultrasound assessment should be used as a tool for follow-up. However, based on the present data alone, it cannot be stated that ultrasound should be considered as the best imaging modality to monitor clearance of urate deposition, researchers pointed out.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.