Most Read Articles
Jairia Dela Cruz, 3 days ago
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
31 May 2016
Tacrolimus is safe and effective in inducing and maintaining remission in paediatric patients with biologic refractory inflammatory bowel disease (IBD), according to a study presented at the 49th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition in Athens, Greece.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Ultra-low-dose intravitreal bevacizumab improves severe, posterior ROP

06 Feb 2018

Using 0.16-mg intravitreal bevacizumab (IVB) has improved severe and posterior retinopathy of prematurity (ROP), with no adverse ocular outcomes occurring in the series, reports a recent study.

IVB injection was performed in 29 eyes of 15 infants. ‘Treatment success’ was defined as complete regression of retinopathy and vascularization into (or laser ablation of) zone 3.

Of the 29 eyes, 23 (79.3 percent) achieved primary success in response to IVB 0.16 mg alone, and 27 (93.1 percent) achieved secondary success, where additional treatment was required. During follow-up, one infant death was recorded due to respiratory disease.

Six of the total number of eyes (20.6 percent) underwent retreatment. Retreatments occurred at a mean of 9.8 weeks following initial IVB (range, 6‒15) and at a mean of 44 weeks postmenstrual age (range, 40‒50).

The authors conducted a retrospective observational case series of consecutive infants who underwent ultra-low-dose IVB injection for the management of ROP at a regional neonatal intensive care unit in the North East of England between November 2013 and August 2016.

IVB has emerged as an effective treatment modality for the management of severe and posterior ROP, but despite evidence of systemic vascular endothelial growth factor suppression and concerns about how this might affect the developing neonate, the optimal dose has remained unknown, according to the authors.

A 2013 study in Taiwan had shown the efficacy and safety of IVB injection in treating prethreshold ROP. Researchers, however, said that laser therapy might still be needed as backup treatment for patients who do not respond to an IVB injection or for those in whom ROP worsen after an IVB injection. [Am J Ophthalmol 2013;155:150-158.e1]

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Most Read Articles
Jairia Dela Cruz, 3 days ago
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
31 May 2016
Tacrolimus is safe and effective in inducing and maintaining remission in paediatric patients with biologic refractory inflammatory bowel disease (IBD), according to a study presented at the 49th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition in Athens, Greece.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.