Most Read Articles
Rachel Soon, 2 days ago

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Elvira Manzano, 22 Nov 2017
A blood pressure (BP) reading of 130/80 mm Hg or higher is the ‘new high’ in the latest AHA/ACC* hypertension guidelines, a threshold that is tighter than the JNC 7** cutpoint of 140/90 mm Hg for stage 1 hypertension in the general population. The change will mean more patients being labelled with hypertension.
Roshini Claire Anthony, 18 hours ago

The reduction in bleeding events with 12-month ticagrelor monotherapy after 3-month dual antiplatelet therapy (DAPT) among high-risk patients who have undergone percutaneous coronary intervention (PCI) in the TWILIGHT* trial is consistent among patients with diabetes mellitus (DM), the TWILIGHT-DM trial showed.

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Ultra-low dose estriol vaginal gel effective against vulvovaginal atrophy

17 Mar 2020

Treatment with the ultra-low dose 0.005% estriol vaginal gel yields improvements in symptoms and signs of vulvovaginal atrophy, with minimal oscillations in hormonal levels, according to the results of a phase II trial.

A total of 61 women (mean age, 59 years) with hormone receptor-positive early breast cancer treated with nonsteroidal aromatase inhibitors (NSAIs) were randomly assigned to receive either estriol vaginal gel (n=50) or placebo (n=11) for 12 weeks for their treatment-related vulvovaginal symptoms and signs.

Researchers assessed vaginal maturation, vaginal pH, and vulvovaginal atrophy symptoms and signs at baseline and at weeks 3 and 12. They also evaluated sexual functioning using the Female Sexual Functioning Index (FSFI) questionnaire, in addition to circulating oestrogens, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Active treatment exerted favourable effects on maturation value and pH, vaginal dryness, and global scores of symptoms and signs. Parallel improvements were seen in the total FSFI score and all the FSFI domains, with the exception of pain.

There were small oscillations in FSH and LH, which remained within the postmenopausal range. Estriol levels increased at the outset but returned to normal by week 12, whereas oestradiol and estrone levels remained mostly undetectable throughout the study.

The present data highlight the usefulness of ultra-low dose 0.005% estriol vaginal gel in the treatment of vulvovaginal atrophy in women with breast cancer receiving NSAIs with an indication for treatment with vaginal oestrogens, the researchers said.

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Most Read Articles
Rachel Soon, 2 days ago

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Elvira Manzano, 22 Nov 2017
A blood pressure (BP) reading of 130/80 mm Hg or higher is the ‘new high’ in the latest AHA/ACC* hypertension guidelines, a threshold that is tighter than the JNC 7** cutpoint of 140/90 mm Hg for stage 1 hypertension in the general population. The change will mean more patients being labelled with hypertension.
Roshini Claire Anthony, 18 hours ago

The reduction in bleeding events with 12-month ticagrelor monotherapy after 3-month dual antiplatelet therapy (DAPT) among high-risk patients who have undergone percutaneous coronary intervention (PCI) in the TWILIGHT* trial is consistent among patients with diabetes mellitus (DM), the TWILIGHT-DM trial showed.

02 Apr 2020
Cabozantinib plus androgen deprivation therapy (ADT) shows potent clinical activity in hormone-naïve metastatic prostate cancer (HNMPCa), according to the results of a phase II trial.