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TyG-BMI predicts nonalcoholic fatty liver disease in nonobese individuals

08 Aug 2017

Triglyceride and glucose index in combination with body mass index (TyG-BMI) is an effective marker in detecting nonalcoholic fatty liver disease (NAFLD) in nonobese individuals, a new observational study has found.

The study included 6,809 nonobese Chinese adults (mean age 48.4±15.1 years; mean BMI, 22.0±2.0 kg/m2) with complete health examination data. Exclusion criteria were autoimmune hepatic diseases, chronic hepatic diseases, hepatic virus infections and diabetes or dyslipidaemia medications.

NAFLD diagnoses were delivered according to the Asia-Pacific Working Party guidelines. All participants underwent anthropometric measurements and routine biochemical laboratory tests.

NAFLD prevalence was 2.2 percent in the first TyG-BMI quartile and increased to 9.0 percent in the second. The prevalence further increased to 27.8 and 56.7 percent in the third and fourth quartiles of TyG-BMI, respectively.

Compared with participants in the first TyG-BMI quartile, those in the second (odds ratio [OR], 2.44; 95 percent CI, 1.6 to 3.6), third (OR, 6.4; 4.2 to 9.7) and fourth (OR, 15.3; 9.8 to 23.9) had higher risks of NAFLD after adjusting for blood pressure, serum biomarkers and BMI.

In the fully adjusted model, every 1-standard deviation increase in TyG-BMI also increased the risk of NAFLD (OR, 3.4; 3.0 to 3.9).

The diagnostic value of TyG-BMI (area under the receiver operating curve [AUROC], 0.835; 0.824 to 0.845; p<0.0001) was greater than that of BMI (AUROC, 0.783; 0.771 to 0.794; p<0.0001), TyG (AUROC 0.764; 0.751 to 0.777; p<0.0001), triglycerides (AUROC, 0.753; 0.739 to 0.766; p<0.0001) and fasting plasma glucose (AUROC, 0.625; 0.609 to 0.641; p<0.0001).

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Most Read Articles
Pearl Toh, 13 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 4 days ago
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Tristan Manalac, Yesterday
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