Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 19 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Tweaking design may help minimize placebo effects in atopic dermatitis trials

22 Dec 2019

Placebo responses appear to be common in randomized controlled trials (RCTs) for atopic dermatitis (AD), reports a new meta-analysis. Better methodological control, such as double- or triple-blinding and more balanced sex distributions, may help address this.

After applying the selection criteria, 64 RCTs were found to be eligible and were ultimately included in the meta-analysis. Half of the included studies were on adults, and 39.1 percent enrolled children. Studies were retrieved from the databases of Scopus, Lilacs, Great, Embase, Medline and the Cochrane Library.

Most of the studies (81.3 percent; n=52) were double-blinded, 3.1 percent (n=2) were unblinded and 9.4 percent (n=6) did not specify either way. Only over half (57.8 percent; n=37) were specific about the target severity of the population.

There was also great heterogeneity in the outcome measures used. The numerical rating scale or visual analogue scale (NRS/VAS) was employed most commonly, followed by the objective Scoring AD (SCORAD) index and the Eczema Area Severity Index (EASI). The Dermatology Life Quality Index was also used, as were different laboratory tests.

Multivariable mixed models of Cohen’s D found that the effect sizes of EASI scores increased in the placebo arms of studies with more males. The same was true for effect sizes of NRS/VAS.

Study design also appeared to be an important consideration for placebo effects. The effect-sizes of EASI in the placebo group were lower in studies that were double- or triple-blinded. Those with concomitant prescription of topical therapies, on the other hand, saw greater effects of EASI and NRS/VAS in placebo groups.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 19 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.