Most Read Articles
Stephen Padilla, 6 days ago
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Tumour volume reduction during CRT linked to worse survival in locally advanced lung adenocarcinoma

Jackey Suen
16 Oct 2018

Reduction in gross tumour volume (GTV) during concurrent chemoradiation therapy (CRT) may be linked to worse overall survival (OS) in patients with locally advanced lung adenocarcinoma, according to a recent study reported at the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer (WCLC 2018).

In the study, 394 patients treated with concurrent CRT for locally advanced non-small-cell lung cancer (NSCLC) had their GTV measured on cone beam CT scan between the first and last fraction of radiotherapy. [Kwint M, et al, WCLC 2018, abstract P1.17-07]

“It is important to determine tumour response during treatment and its relationship with clinical outcomes. However, previously published literature in NSCLC patients has been inconsistent about this association,” wrote researchers from the Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Results showed that in NSCLC patients who had adenocarcinoma histology, >median GTV change during concurrent CRT was associated with worse OS (p=0.060).

Surprisingly, no such associations were found for the entire cohort, or in those with squamous (p=0.770) or unspecified histology (p=0.952). “In the entire cohort, we could not identify any associations between GTV changes during concurrent CRT and OS, progression-free survival or locoregional control,” the researchers added.

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Most Read Articles
Stephen Padilla, 6 days ago
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.