Most Read Articles
5 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Roshini Claire Anthony, 4 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.
4 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.

Tumour volume reduction during CRT linked to worse survival in locally advanced lung adenocarcinoma

Jackey Suen
16 Oct 2018

Reduction in gross tumour volume (GTV) during concurrent chemoradiation therapy (CRT) may be linked to worse overall survival (OS) in patients with locally advanced lung adenocarcinoma, according to a recent study reported at the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer (WCLC 2018).

In the study, 394 patients treated with concurrent CRT for locally advanced non-small-cell lung cancer (NSCLC) had their GTV measured on cone beam CT scan between the first and last fraction of radiotherapy. [Kwint M, et al, WCLC 2018, abstract P1.17-07]

“It is important to determine tumour response during treatment and its relationship with clinical outcomes. However, previously published literature in NSCLC patients has been inconsistent about this association,” wrote researchers from the Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Results showed that in NSCLC patients who had adenocarcinoma histology, >median GTV change during concurrent CRT was associated with worse OS (p=0.060).

Surprisingly, no such associations were found for the entire cohort, or in those with squamous (p=0.770) or unspecified histology (p=0.952). “In the entire cohort, we could not identify any associations between GTV changes during concurrent CRT and OS, progression-free survival or locoregional control,” the researchers added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Roshini Claire Anthony, 4 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.
4 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.