Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.

Tumour volume reduction during CRT linked to worse survival in locally advanced lung adenocarcinoma

Jackey Suen
16 Oct 2018

Reduction in gross tumour volume (GTV) during concurrent chemoradiation therapy (CRT) may be linked to worse overall survival (OS) in patients with locally advanced lung adenocarcinoma, according to a recent study reported at the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer (WCLC 2018).

In the study, 394 patients treated with concurrent CRT for locally advanced non-small-cell lung cancer (NSCLC) had their GTV measured on cone beam CT scan between the first and last fraction of radiotherapy. [Kwint M, et al, WCLC 2018, abstract P1.17-07]

“It is important to determine tumour response during treatment and its relationship with clinical outcomes. However, previously published literature in NSCLC patients has been inconsistent about this association,” wrote researchers from the Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Results showed that in NSCLC patients who had adenocarcinoma histology, >median GTV change during concurrent CRT was associated with worse OS (p=0.060).

Surprisingly, no such associations were found for the entire cohort, or in those with squamous (p=0.770) or unspecified histology (p=0.952). “In the entire cohort, we could not identify any associations between GTV changes during concurrent CRT and OS, progression-free survival or locoregional control,” the researchers added.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.