Most Read Articles
07 Aug 2018
Oral vitamin B-12 supplementation yields similar efficacy to that of hydroxocobalamin injections, according to a recent study. This suggests that oral supplementation can be used to replace hydroxocobalamin injections in the treatment of Roux-en-Y gastric bypass (RYGB) patients with low values of serum vitamin B-12.

Tumour type, length predict submucosal fibrosis in superficial squamous oesophageal neoplasia

09 Jul 2018

A depressed tumour type and a length of >20 mm predict submucosal fibrosis in superficial squamous oesophageal neoplasia (SSEN), according to a recent study.

Multivariate logistic regression analysis showed that a depressed tumour type (vs nondepressed type; hazard ratio [HR], 12.820; 95 percent CI, 2.506–65.456; p=0.002) and tumour length >20 mm (HR, 6.056; 1.129–32.492; p=0.036) significantly and independently predicted endoscopic submucosal fibrosis.

Moreover, receiving endoscopic submucosal dissection (ESD) right after diagnosis helped avoid submucosal fibrosis, as undergoing the operation >21 days after initial biopsy also increased the risk of developing endoscopic submucosal fibrosis (HR, 10.214; 2.021–51.630; p=0.005).

While the presence of endoscopic submucosal fibrosis did not appear to have an effect on the overall resection rate, the severity of submucosal fibrosis showed a significant and positive association with immediate bleeding rate (severe vs no fibrosis: 100 percent vs 66.7 percent; p=0.018). In addition, one patient with severe submucosal fibrosis showed perforation, while no other cases were observed.

Mean procedure time was also affected by the degree of submucosal fibrosis, such that those with no and mild vs severe fibroses had significantly shorter procedure times (59.4 and 79.8 vs 150.0 minutes; p<0.001 and p=0.008, respectively).

For the present study, researchers retrospectively analysed 41 SSEN patients who received ESD and identified endoscopic and pathological factors associated with submucosal fibrosis. Masson’s trichrome staining was used to assess endoscopic submucosal fibrosis.

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Most Read Articles
07 Aug 2018
Oral vitamin B-12 supplementation yields similar efficacy to that of hydroxocobalamin injections, according to a recent study. This suggests that oral supplementation can be used to replace hydroxocobalamin injections in the treatment of Roux-en-Y gastric bypass (RYGB) patients with low values of serum vitamin B-12.