Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Tumour necrosis factor inhibitors for RA do not increase risk of cancer relapse

12 Oct 2018

Treatment with tumour necrosis factor inhibitor (TNFi) does not carry a heightened risk of cancer recurrence in patients with rheumatoid arthritis (RA) and a history of cancer, as shown in a recent study.

Researchers followed 467 adult RA patients who initiated TNFi treatment at a mean of 7.9 years after being diagnosed with cancer, evaluating cancer recurrence in comparison with 2,164 matched RA controls and a history of the same cancer but who had never received biologics.

Cancer recurrences occurred in 42 TNFi-treated patients during a mean follow-up of 5.3 years and in 155 biologics-naïve controls during a mean follow-up of 4.3 years (9.0 percent vs 7.2 percent). Adjusted Cox proportional hazards analysis revealed that TNFi treatment was not associated with any increase in the risk of recurrence (hazard ratio [HR], 1.06; 95 percent CI, 0.73–1.54).

However, researchers noted that several estimates from subgroup analyses had CIs with upper limits around 2 or above, suggesting that a clinically relevant risk for cancer recurrence could not be ruled out.

The study was limited by the outcome algorithm being partly nonvalidated. Also, it is possible that clinicians gave TNFi drugs only to the patients they thought had a better cancer prognosis–in other words, a low risk of relapse.

The findings should therefore be interpreted with treatment channelling in mind. Such channelling is part of clinical practice and may not be directly applicable to all cancer types or to patients with ongoing or a recent cancer diagnosis, researchers said.

Additional investigation is needed to further examine the association between TNFi treatment for RA and the risk of cancer recurrence.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.