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Tryptophan metabolite kynurenine may be linked to ischaemic heart disease

07 May 2020

There appears to be a possibility that kynurenine, one of the main metabolites of tryptophan, is positively associated with ischaemic heart disease (IHD), but further studies are needed to confirm any link and underlying mechanism, suggests a recent study.

“Observationally, plasma tryptophan is inversely associated with IHD,” the authors said. “[H]owever, its main metabolites, serotonin, and kynurenine are positively associated with IHD, which makes the effects of tryptophan difficult to infer.”

A two-sample Mendelian randomization study was conducted to obtain less confounded estimates of the associations of tryptophan and physiologically related factors (serotonin and kynurenine) with IHD, its risk factors and depression.

The authors used genetic instruments independently associated with tryptophan, serotonin and kynurenine metabolites applied to a meta-analysis of the UK Biobank SOFT CAD study with the CARDIoGRAMplusC4D consortium (cases, n≤76,014; controls, n≤264,785), and other consortia for risk factors including diabetes, lipids and blood pressure, as well as for depression.

No association was found between tryptophan or serotonin and IHD. Kynurenine, on the other hand, showed a nominal and positive correlation with IHD (odds ratio, 1.57, 95 percent confidence interval, 1.05–2.33). However, this association did not persist after correction for multiple comparisons.

Furthermore, null associations were observed with IHD risk factors and depression.

Tryptophan is an essential amino acid derived from dietary items, including dairy products, eggs, nuts, legumes and grains. It has also been recommended as a dietary supplement to boost mental health, according to the authors.

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Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).