Triglyceride-to-high-density lipoprotein cholesterol predicts diabetes in men
The ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) independently predicts incident diabetes in men, a new China study has shown.
The study included 116,855 participants (mean age, 44.1±12.9 years; 53 percent male) who did not have diabetes at baseline. Half of the participants (50 percent; n=58,142) had TG/HDL-C ratio values <0.8163, the predetermined median in the sample, and were designated as the low group; the other half (50 percent; n=58,443) were set as the high group.
Over a median follow-up of 3.10 years, 2,685 incident diabetes cases were recorded, yielding an overall incidence rate of 741.20 cases per 100,000 person-years. This value was higher in males than in females (969.77 and 475.02 cases per 100,000 person-years). Cumulative diabetes incidence was likewise elevated in the high group.
Multivariate Cox proportional hazards regression analysis identified the male sex (hazard ratio [HR], 0.640, 95 percent CI, 0.417–0.982; p=0.041), TG (HR, 1.168, 1.072–1.272; p<0.001) and HDL-C (HR, 1.897, 1.287–2.796; p=0.001) as significant and independent predictors of incident diabetes. The same was true for body mass index (HR, 1.166, 1.119–1.216; p<0.001) and smoking status (HR, 0.851, 0.736–0.984; p=0.029).
However, stratification according to sex showed that an elevated TC/HDL-C value (≥1.14) was independently predictive of incident diabetes only in males (HR, 1.30, 1.03–1.64) and not in females (HR, 0.85, 0.53–1.38).
“To search and identify the independent risk factors in the general population is significant for us to adopt … various prevention measures,” said researchers, adding that future studies will help confirm if lowering the TG/HDL-C ratio can help prevent diabetes.