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Roshini Claire Anthony, 2 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 3 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 6 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
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While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.

Trifarotene cream effective for face, trunk acne

28 May 2019
Patients with newly diagnosed acne were found to be at an increased risk of developing clinical depression compared to the general population.

Trifarotene is safe, well-tolerated and effective in treating both facial and truncal acne, according to two phase III trials.

Researchers conducted two double-blinded, randomized, vehicle-controlled trials: PERFECT 1 (n=1,208; mean age, 19.4±6.41 years; 52.1 percent female) and PERFECT 2 (n=1,212; mean age, 19.7±6.3 years; 57.3 percent female). In both studies, the primary endpoints were success rate on the face, as measured by the Investigator’s Global Assessment (IGA), and the absolute change from baseline in inflammatory and noninflammatory counts.

In PERFECT 1, the IGA success rate in the face in patients who received the trifarotene cream (n=612) was 29.4 percent. This was significantly higher than the corresponding rate in those randomly assigned to the vehicle cream (19.5 percent; p<0.001). A similar trend was observed for PERFECT 2 (42.2 percent vs 25.7 percent; p<0.001).

Trifarotene continued to trump the vehicle control in terms of primary endpoints. For instance, in PERFECT 1, there was a significantly greater absolute drop in inflammatory lesions in those who received the cream of interest (–19.0 vs –15.4; p<0.001). This remained true in PERFECT 2 (–24.2 vs –18.7; p<0.001).

Noninflammatory lesions likewise significantly decreased from baseline in both PERFECT 1 (–25.0 vs –17.9; p<0.001) and PERFECT 2 (–30.1 vs –21.6; p<0.001).

The significant benefits of trifarotene also extended to the trunk. The Physician’s Global Assessment success rates (PERFECT 1: 35.7 percent vs 25.0 percent; p<0.001; PERFECT 2: 42.6 percent vs 29.9 percent; p<0.001) and reductions in inflammatory (PERFECT 1: –21.4 vs –18.8; p<0.001; PERFECT 2: –25.5 vs –19.8) and noninflammatory (PERFECT 1: –21.9 vs –17.9; p<0.001; PERFECT 2: –25.9 vs –20.8; p<0.001) lesions were all significantly greater in those who received the trifarotene cream.

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Most Read Articles
Roshini Claire Anthony, 2 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 3 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 6 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
6 days ago
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.