Most Read Articles
Dr Joslyn Ngu, 12 Sep 2017

Even though there is no cure for eczema, the skin disorder can be safely and effectively controlled by avoiding and eliminating allergens, says a clinician.

Stephen Padilla, 26 Nov 2018
A 10-year retrospective study at Singapore General Hospital (SGH) has shown that majority of patients with tinea unguium, a common nail infection, are aged ≥60 years. In this cohort, patients of Indian and other ethnicities are over-represented for tinea unguium compared to Chinese and Malay patients.

Triamcinolone, 5-fluorouracil injections both effective for keloids

09 Jan 2019

Despite comparable efficacies, triamcinolone (TAC) injections appear to be slightly superior over 5-fluorouracil (5-FU) injections for inducing keloid remission, a recent trial has found.

Researchers randomly assigned 43 patients with 50 keloid scars to receive either TAC (n=25; median age 40 years; 56 percent female) or 5-FU (n=25; median age 43 years; 40 percent female) over 6 months. The mean dosage was 8.4±5.4 mg and 25±13 mg in the respective groups.

There was no significant between-group difference in terms of treatment efficacy. Six-month remission rate was 46 percent in patients who received 5-FU vs 60 percent in those who were given TAC (p>0.05). Fattening and softening of keloids were observed in both groups.

On the other hand, TAC resulted in a significant decrease in the mean proliferation rate (11.3 percent to 7.9 percent), while 5-FU led to a significant increase (9.9 percent to 12.1 percent; p<0.05 for both).

Haemoglobin concentration at 6 months likewise significantly dropped in the TAC group (0.17±0.18 to 0.10±0.18; p<0.05), as did the blood vessel density (p<0.05). Changes in both parameters were marginal in the 5-FU group and failed to reach significance (haemoglobin concentration: 0.13±0.10 to 0.10±0.09; p>0.05 for both).

However, in terms of safety, 5-FU appeared to be the better treatment option. Significantly more patients in the TAC group developed skin atrophy (44 percent vs 8 percent) and telangiectasia (50 percent vs 21 percent; p<0.05 for both).

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Most Read Articles
Dr Joslyn Ngu, 12 Sep 2017

Even though there is no cure for eczema, the skin disorder can be safely and effectively controlled by avoiding and eliminating allergens, says a clinician.

Stephen Padilla, 26 Nov 2018
A 10-year retrospective study at Singapore General Hospital (SGH) has shown that majority of patients with tinea unguium, a common nail infection, are aged ≥60 years. In this cohort, patients of Indian and other ethnicities are over-represented for tinea unguium compared to Chinese and Malay patients.