Most Read Articles
Dr. Joseph Delano Fule Robles, 5 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

4 days ago
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
5 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
4 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

Treatment with B cell depletion therapy lowers circulating TFH cells in pSS patients

24 Jan 2017

B cell depletion therapy has decreased the high levels of circulating follicular Th (TFH) cells in patients with primary Sjögren syndrome (pSS), improving the objective clinical disease activity measures, according to a study.

A total of 24 pSS patients treated with rituximab (RTX) and 24 healthy controls were included in this study that evaluated the effect of B cell depletion therapy on effector CD4+ T cell homeostasis and its relation to objective measures of disease activity in pSS patients.

Researchers used flow cytometry to examine the frequencies of circulating effector CD4+ T cell subsets at baseline and at 16, 24, 36 and 48 weeks after the first RTX infusion. Based on surface marker expression patterns, Th1, Th2, Th17 and TFH cells were discerned.

In addition, researchers conducted intracellular cytokine staining for interferon-y, interleukin (IL)-4, IL-21 and IL-17, and analysed serum levels of these cytokines.

There were increased frequencies of circulating TFH and Th17 cells in patients with pSS at baseline compared with controls, but the Th1 and Th2 cell frequencies were unchanged.

There was a noticeable reduction in circulating TFH cells in patients who received B cell depletion therapy. On the other hand, Th17 cells were only slightly reduced. There were also reductions in frequencies of IL-21– and IL-17–producing CD4+ T cells, as well as serum levels of IL-21 and IL-17.

An association was found between the reduction in circulating TFH cells and lower systemic disease activity over time, as measured by the European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index scores and serum IgG levels.

According to researchers, these observations demonstrated the essential role of the crosstalk between B cells and TFH cells in the pathogenesis of pSS.

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Most Read Articles
Dr. Joseph Delano Fule Robles, 5 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

4 days ago
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
5 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
4 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.