Most Read Articles
2 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
3 days ago
The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Treating follicular lymphoma boosts survival in older adults

11 Jan 2020
Doctors are most likely to miss difficult-to-diagnose conditions such as myeloma, lymphoma and lung cancer.

Among elderly patients, treating follicular lymphomas (FLs) results in better survival outcomes, a recent study has shown.

Researchers retrospectively assessed 3,705 elderly adults (aged 80 years; 60 percent female) diagnosed with FL between 2000 and 2013. Those treated according to existing guidelines were compared against those who received no treatment following propensity-score matching. Outcomes included overall survival time and 3-year restricted mean survival time (RMST).

Majority (68 percent; n=2,519) of the patients had received FL-directed therapy, initiated within a median of 61 days. Rituximab was the most common first-line agent. Seventy percent of the untreated participants died over a median follow-up of 2.2 years.

In the propensity score-matched cohorts, Kaplan-Meier curves revealed an overall median survival of 4.31 years in participants who received treatment. This was significantly greater than in the untreated group (median, 2.86 years; log-rank p<0.001).

Survival probabilities showed a similar trend. At each year following FL diagnosis, patients who received treatment showed better odds of survival than their untreated counterparts. The respective 3-year survival probabilities, for instance, were 0.61 and 0.48. The 5-year probabilities were 0.43 and 0.34, respectively.

Moreover, the 3-year RMST was 2.36 years for patients who had received treatment and only 2.05 years in those who had not.

Cox proportional-hazards models confirmed these findings: Treatment significantly reduced the likelihood of death by 23 percent (hazard ratio, 0.77, 95 percent confidence interval, 0.70–0.85).

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Most Read Articles
2 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
3 days ago
The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.