Most Read Articles
15 Nov 2017
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.
Yesterday
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
3 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
4 days ago
Moderate increases in physical activity levels may translate to significant reductions in both fasting glucose and HbA1c, a study has found.

Traumatic life events affect cellular ageing in women of reproductive age

14 Jul 2017
Women of reproductive age who suffer a traumatic life event such as the loss of a child have a faster pace of cellular ageing than those who do not, and this appears to be affected by maternal hypothalamic-pituitary-adrenal axis (HPAA) activity, say Canada-based researchers.

They tested the hypothesis that psychological challenges increase the age-related pace of biological ageing by measuring telomere attrition in a cohort of Kaqchikel Mayan women living in a population with a high frequency of child mortality. The women are part of an ongoing longitudinal study of the relationship between naturally occurring stress and women’s reproductive function. Genetic variability was reduced since the women were all Kaqchikel Mayan with at least five generations of traceable ancestors. Moreover, they had similar lifestyles in terms of diet, physical activity, education, and socioeconomic status, and none smoked.

Telomere length was quantified by qPCR of buccal specimens collected from 55 women in 2013, and HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for 7 weeks during that same year. Child mortality data were collected in 2000 and 2013.

Only women who experienced child mortality were found to have shorter telomere lengths with increasing age (p=0.015). Notably, shorter telomere length was linked to higher than average basal cortisol levels (p=0.007) as well as greater variations in basal cortisol levels over time (p=0.053). Nonparametric bootstrapping analyses indicated that HPAA activity mediated the effect of child mortality on telomere length.

The researchers suggested that more large-scale longitudinal studies are required to confirm their findings.
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Most Read Articles
15 Nov 2017
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.
Yesterday
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
3 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
4 days ago
Moderate increases in physical activity levels may translate to significant reductions in both fasting glucose and HbA1c, a study has found.