Most Read Articles
6 days ago
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
04 Dec 2017
Later timing of puberty seems to correlate with lower areal bone mineral density in children and may affect the eventual risk of osteoporosis, a recent study suggests.
Jairia Dela Cruz, 6 days ago
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
3 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.

Traumatic life events affect cellular ageing in women of reproductive age

14 Jul 2017
Women of reproductive age who suffer a traumatic life event such as the loss of a child have a faster pace of cellular ageing than those who do not, and this appears to be affected by maternal hypothalamic-pituitary-adrenal axis (HPAA) activity, say Canada-based researchers.

They tested the hypothesis that psychological challenges increase the age-related pace of biological ageing by measuring telomere attrition in a cohort of Kaqchikel Mayan women living in a population with a high frequency of child mortality. The women are part of an ongoing longitudinal study of the relationship between naturally occurring stress and women’s reproductive function. Genetic variability was reduced since the women were all Kaqchikel Mayan with at least five generations of traceable ancestors. Moreover, they had similar lifestyles in terms of diet, physical activity, education, and socioeconomic status, and none smoked.

Telomere length was quantified by qPCR of buccal specimens collected from 55 women in 2013, and HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for 7 weeks during that same year. Child mortality data were collected in 2000 and 2013.

Only women who experienced child mortality were found to have shorter telomere lengths with increasing age (p=0.015). Notably, shorter telomere length was linked to higher than average basal cortisol levels (p=0.007) as well as greater variations in basal cortisol levels over time (p=0.053). Nonparametric bootstrapping analyses indicated that HPAA activity mediated the effect of child mortality on telomere length.

The researchers suggested that more large-scale longitudinal studies are required to confirm their findings.
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Most Read Articles
6 days ago
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
04 Dec 2017
Later timing of puberty seems to correlate with lower areal bone mineral density in children and may affect the eventual risk of osteoporosis, a recent study suggests.
Jairia Dela Cruz, 6 days ago
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
3 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.