Most Read Articles
Pearl Toh, 30 Mar 2018
Diagnosis of polycystic ovary syndrome (PCOS) is challenging, and there should be no rush to label an adolescent as having the condition before a thorough evaluation of symptoms, according to a leading endocrinologist who was speaking at the RCOG World Congress 2018 in Singapore.
Rachel Soon, 12 Dec 2018

A new ‘cooling’ drink product incorporating elements of traditional Chinese medicine (TCM) was launched in Kuala Lumpur recently.

Roshini Claire Anthony, 16 Apr 2019

Patients on the anticoagulant drug edoxaban could safely continue their treatment while undergoing certain procedures, with a low incidence of bleeding and cardiovascular events reported in the prospective EMIT AF/VTE* study.

06 Feb 2019
Depression symptoms in acne patients may improve following treatment with isotretinoin, according to a systematic review and meta-analysis.

Trauma risk in elderly boosted by use of insulin, glinides

14 Oct 2018

Elderly adults using hypoglycaemic glucose-lowering drugs (GLDs), such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.

Researchers enrolled 10,743 elderly adults (aged ≥65 years; 68.0 percent female) who had first been hospitalized for trauma and had been followed for at least 365 days by the index date. An age-, sex- and follow-up length-matched control cohort was also included (n=106,629).

At baseline, cases were more likely to be using GLDs than controls (15.8 percent vs 12.3 percent) and were more frequently taking hypoglycaemic GLDs alone (6.8 percent vs 4.2 percent), especially insulin (3.6 percent vs 1.7 percent) and glinides (1.3 percent vs 0.8 percent).

Participants currently on GLD medication were significantly more likely to be admitted for trauma (hazard ratio [HR], 1.13; 95 percent CI, 1.07–1.21). This relationship was more pronounced in those taking hypoglycaemic GLDs (HR, 1.25; 1.14–1.37).

In contrast, using nonhypoglycaemic GLDs alone (HR, 1.06; 0.96–1.18) or both types of GLD (HR, 1.07; 0.96–1.19) did not lead to a higher risk of trauma hospitalization.

Further analysis stratified according to medication type showed that the hypoglycaemic GLDs insulin (HR, 1.47; 1.31–1.66) and glinides (HR, 1.34; 1.11–1.61) were strongly and significantly correlated with the risk of trauma, while sulfonylureas (HR, 1.08; 0.94–1.23) were not.

Assuming a causal relationship, researchers showed that using insulin would increase the absolute risk of trauma from 2.9 percent to 4.3 percent, while use of glinides would correspond to an increase to 3.9 percent.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 30 Mar 2018
Diagnosis of polycystic ovary syndrome (PCOS) is challenging, and there should be no rush to label an adolescent as having the condition before a thorough evaluation of symptoms, according to a leading endocrinologist who was speaking at the RCOG World Congress 2018 in Singapore.
Rachel Soon, 12 Dec 2018

A new ‘cooling’ drink product incorporating elements of traditional Chinese medicine (TCM) was launched in Kuala Lumpur recently.

Roshini Claire Anthony, 16 Apr 2019

Patients on the anticoagulant drug edoxaban could safely continue their treatment while undergoing certain procedures, with a low incidence of bleeding and cardiovascular events reported in the prospective EMIT AF/VTE* study.

06 Feb 2019
Depression symptoms in acne patients may improve following treatment with isotretinoin, according to a systematic review and meta-analysis.