Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
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01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Tranexamic acid may prevent postpartum haemorrhage

09 Feb 2017

In patients undergoing caesarean section (CS) or vaginal delivery (VD), the intravenous administration of tranexamic acid (TA) appears to be safe and effective in reducing blood loss and the need for blood transfusion. In addition, it may decrease the occurrence of postpartum haemorrhage (PPH) in CS patients, according to a systematic review and meta-analysis.

A total of 25 articles on the use of TA in CS (n=22) or VD (n=3) with 4,747 participants were identified from various online databases and included in the analysis. Compared to control, intravenous TA reduced intraoperative, postoperative and total blood loss by respective mean volumes of 141.25 mL, 36.42 mL and 154.25 mL in CS (p< 0.00001 for all), and 22.88 mL (p= 0.10), 41.24 mL (p<0.00001) and 84.79 mL (p<0.00001) in VD. According to researchers, the efficacy in reducing total blood loss was affected by the mode of delivery after testing for differences between subgroups (p=0.0003).

Moreover, TA reduced the rate of occurrence of PPH in CS (ratio risk [RR], 0.32) and VD (RR, 0.37) and the need for transfusion in CS (RR 0.31). In contrast to blood loss, the mode of delivery did not have any significant effect on the efficacy of TA with regard to PPH occurrence rate and transfusion needs. Thromboembolic events were similar between TA and control groups with an increased risk of minor transient adverse events in TA.

Researchers posited that based on available evidence, the use of TA is effective and safe in CS; however, due to the paucity of robust data, a definite conclusion for its use in VD cannot be drawn. High-quality randomized controlled trials with larger samples are thus warranted, said researchers.
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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 4 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.