Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 19 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Training for marathon reverses age-related aortic stiffening

15 Jan 2020

Running a marathon, or even training for one, even at a relatively low exercise intensity can decrease central blood pressure (BP) and aortic stiffness, which is equivalent to an approximately 4-year reduction in vascular age, according to a recent study. In addition, greater rejuvenation is seen in older, slower individuals.

The analysis included 138 first-time marathon completers (aged 21–69 years; 51 percent female), with an estimated training schedule of 6–13 miles/week. At baseline, a decade of chronological ageing was associated with a reduction in distensibility of the ascending (Ao-A) and descending aorta at the pulmonary artery bifurcation (Ao-P) and diaphragm (Ao-D) by 2.3, 1.9 and 3.1 × 10−3 mm Hg−1, respectively (p-all<0.05).

Training for a marathon resulted in a decrease in systolic and diastolic central (aortic) BP by 4 mm Hg (95 percent confidence interval [CI], 2.8–5.5 mm Hg) and 3 mm Hg (95 percent CI, 1.6–3.5 mm Hg), respectively. Descending aortic distensibility increased (Ao-P: 9 percent; p=0.009; Ao-D: 16 percent; p=0.002), while distensibility in the Ao-A remained unchanged. These led to a reversal in “aortic age” by 3.9 years (95 percent CI, 1.1–7.6 years) and 4.0 years (95 percent CI, 1.7–8.0 years) for Ao-P and Ao-D, respectively.

Moreover, this benefit appeared to be more pronounced in older, male participants with slower running times (p-all<0.05)

In this study, untrained healthy individuals underwent training for the London Marathon for 6 months. Central BP and aortic stiffness were assessed pretraining and 2 weeks postmarathon using cardiovascular magnetic resonance distensibility. The researchers calculated the biological “aortic age” from the baseline chronological age-stiffness relationship and evaluated the change in stiffness at the Ao-A, Ao-P and Ao-D.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 19 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.