Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.

Trabecular bone loss tied to ASDAS, inflammatory markers in axial spondyloarthritis

07 Sep 2020

Trabecular bone loss is longitudinally associated with Ankylosing Spondylitis Disease Activity Score (ASDAS) and inflammatory markers in patients with axial spondyloarthritis (axSpA), a study has found.

The investigators analysed data from patients enrolled in the Incheon Saint Mary’s axSpA prospective observational cohort and used the trabecular bone score (TBS) to assess trabecular bone loss. Generalized estimating equation (GEE) models were used to examine the relationship between TBS and disease activity measures (ie, ASDAS, Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]).

Data from 240 patients (mean age, 37±12 years; 80 percent males) over 4 years of follow-up were assessed. Higher disease activity at baseline showed a trend toward lower TBS according to ASDAS-ESR (p=0.003) and ASDAS-CRP (p=0.016).

In univariate GEE analyses, TBS was significantly associated with disease activity measures, except for BASDAI, over time. TBS showed a longitudinal association with age, smoking, and spinal structural damage in univariate analysis.

Multivariate GEE analysis also revealed the longitudinal association of TBS with ASDAS-ESR, ASDAS-CRP, ESR, and CRP after adjustment for confounding factors. Moreover, ASDAS scores and inflammatory markers longitudinally correlated with TBS in patients with ankylosing spondylitis (AS; 79 percent), but not in those with noradiographic (nr) axSpA. BASDAI scores did not show any association with TBS in either the AS or nr-axSpA groups.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Pearl Toh, 6 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Elvira Manzano, 17 Nov 2020
Invasive fungal infections, particularly those caused by Candida species, are common in hospitalized, immunocompromised, or critically ill patients and are associated with considerable morbidity and mortality.