Most Read Articles
Jairia Dela Cruz, 2 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
11 Sep 2020
Men who use calcium channel blockers (CCBs) are at risk of developing prostate cancer, and the risk increases with the duration of CCB exposure, according to the results of a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
4 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


Trabecular bone loss tied to ASDAS, inflammatory markers in axial spondyloarthritis

07 Sep 2020

Trabecular bone loss is longitudinally associated with Ankylosing Spondylitis Disease Activity Score (ASDAS) and inflammatory markers in patients with axial spondyloarthritis (axSpA), a study has found.

The investigators analysed data from patients enrolled in the Incheon Saint Mary’s axSpA prospective observational cohort and used the trabecular bone score (TBS) to assess trabecular bone loss. Generalized estimating equation (GEE) models were used to examine the relationship between TBS and disease activity measures (ie, ASDAS, Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]).

Data from 240 patients (mean age, 37±12 years; 80 percent males) over 4 years of follow-up were assessed. Higher disease activity at baseline showed a trend toward lower TBS according to ASDAS-ESR (p=0.003) and ASDAS-CRP (p=0.016).

In univariate GEE analyses, TBS was significantly associated with disease activity measures, except for BASDAI, over time. TBS showed a longitudinal association with age, smoking, and spinal structural damage in univariate analysis.

Multivariate GEE analysis also revealed the longitudinal association of TBS with ASDAS-ESR, ASDAS-CRP, ESR, and CRP after adjustment for confounding factors. Moreover, ASDAS scores and inflammatory markers longitudinally correlated with TBS in patients with ankylosing spondylitis (AS; 79 percent), but not in those with noradiographic (nr) axSpA. BASDAI scores did not show any association with TBS in either the AS or nr-axSpA groups.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 2 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
11 Sep 2020
Men who use calcium channel blockers (CCBs) are at risk of developing prostate cancer, and the risk increases with the duration of CCB exposure, according to the results of a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
4 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.