Most Read Articles
11 Apr 2018
Survivors of Hodgkin’s lymphoma are at greater risk of developing subsequent malignant neoplasm (SMN) and cardiovascular disease (CVD), according to a study.
5 days ago
New drug applications approved by US FDA as of 01 - 15 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date. 

Total testosterone, SHBG inversely correlated with seated DBP

20 Oct 2018

Seated diastolic blood pressure (DBP) show statistically significant inverse cross-sectional associations with total testosterone and sex hormone-binding globulin (SHBG), and a significant positive association with dehydroepiandrosterone sulphate (DHEAS), suggests a recent study.

Total testosterone and SHBG were significantly inversely correlated with systolic (S)BP, while DHEAS was not significantly correlated with BP.

Multivariable analyses revealed that, among men, each 10-percent increase in DHEAS correlated with a 0.41-mm Hg higher seated DBP (β, 4.29; 95 percent CI, 0.84–7.73), and each 10-percent increase in total testosterone and SHBG correlated with a 0.54-mm Hg (β, –5.65; –10.45 to –0.84) and 0.60-mm Hg (β, –6.30; –11.30 to –1.21) decrease in seated DBP, respectively.

There were no significant associations seen among women.

In this study, the investigators assayed baseline blood samples for 229 normotensive men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL. Trained technicians measured standardized seated BP (SBP and DBP) and 24-hour ambulatory (A)BP.

Self-reported cardiovascular risk factors and sociodemographic variables were stated on baseline questionnaires. The association between each sex hormone and measure of BP and 24-hour ABP were estimated using sex-stratified linear regression models adjusted for age, race/ethnicity, BMI, smoking and alcohol. Associations with blunted nocturnal decline (>10-percent reduction in SBP or DBP during sleeping hours) were estimated using logistic regression.

“Higher levels of total testosterone and lower levels of sex hormone-binding globulin (SHBG) have been associated with increased BP in women with an inverse association between total testosterone and BP among men,” the investigators said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
11 Apr 2018
Survivors of Hodgkin’s lymphoma are at greater risk of developing subsequent malignant neoplasm (SMN) and cardiovascular disease (CVD), according to a study.
5 days ago
New drug applications approved by US FDA as of 01 - 15 July 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.