Total testosterone, SHBG inversely correlated with seated DBP
Seated diastolic blood pressure (DBP) show statistically significant inverse cross-sectional associations with total testosterone and sex hormone-binding globulin (SHBG), and a significant positive association with dehydroepiandrosterone sulphate (DHEAS), suggests a recent study.
Total testosterone and SHBG were significantly inversely correlated with systolic (S)BP, while DHEAS was not significantly correlated with BP.
Multivariable analyses revealed that, among men, each 10-percent increase in DHEAS correlated with a 0.41-mm Hg higher seated DBP (β, 4.29; 95 percent CI, 0.84–7.73), and each 10-percent increase in total testosterone and SHBG correlated with a 0.54-mm Hg (β, –5.65; –10.45 to –0.84) and 0.60-mm Hg (β, –6.30; –11.30 to –1.21) decrease in seated DBP, respectively.
There were no significant associations seen among women.
In this study, the investigators assayed baseline blood samples for 229 normotensive men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL. Trained technicians measured standardized seated BP (SBP and DBP) and 24-hour ambulatory (A)BP.
Self-reported cardiovascular risk factors and sociodemographic variables were stated on baseline questionnaires. The association between each sex hormone and measure of BP and 24-hour ABP were estimated using sex-stratified linear regression models adjusted for age, race/ethnicity, BMI, smoking and alcohol. Associations with blunted nocturnal decline (>10-percent reduction in SBP or DBP during sleeping hours) were estimated using logistic regression.
“Higher levels of total testosterone and lower levels of sex hormone-binding globulin (SHBG) have been associated with increased BP in women with an inverse association between total testosterone and BP among men,” the investigators said.