Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Total cholesterol, non-HDL tied to aortic stiffness

14 Oct 2019

Aortic stiffness is significantly associated with total cholesterol, nonhigh-density lipoprotein (non-HDL) and total cholesterol/HDL ratio among other lipid parameters, a recent study has shown.

Multiple linear regression analyses revealed a significant correlation between pulse wave velocity (PWV) and the following parameters: total cholesterol (p=0.03), low-density lipoprotein (LDL; p=0.04), non-HDL (p=0.03), total cholesterol/HDL (p=0.01) and LDL/HDL (p=0.03).

In multiple logistic regression analyses, aortic stiffness was found to be significantly associated with non-HDL (odds ratio [OR], 1.12, 95 percent CI, 1.04–1.20; p=0.01; r, 0.224), total cholesterol/HDL (OR, 1.12, 1.02–1.22; p=0.03; r, 0.219) and total cholesterol (OR, 1.11, 1.01–1.23; p=0.03; r, 0.209).

“This result should be considered in future clinical lipid-lowering trials,” the investigators said.

This cross-sectional study conducted from 2012 to 2017 included 603 participants (517 patients and 86 healthy individuals) to calculate the theoretical PWV. The following lipid parameters were measured: total cholesterol, triglycerides, LDL, HDL, non-HDL, total cholesterol/HDL ratio, triglycerides/HDL ratio, and LDL/HDL ratio.

Theoretical PWV can be calculated according to age, sex, mean blood pressure and heart rate, which allows the formation of an individual PWV index ([measured PWV – theoretical PWV]/theoretical PWV). Aortic stiffness was defined as PWV index ([measured PWV – theoretical PWV]/theoretical PWV) >0.

“Recommendations about lipid parameters varied from different guidelines,” the investigators said. “Aortic stiffness is a marker of vascular ageing and may reflect occurrence of cardiovascular diseases. Aortic PWV, a marker of aortic stiffness, can be measured by applanation tonometry.”

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.