Most Read Articles
Tristan Manalac, 5 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
3 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.

Topical SR-T100 effective, safe for actinic keratosis

10 May 2018
Sunburn rashes could develop into blisters

SR-T100, a topical Solanum undatum extract containing solamargine as the active ingredient, appears to be safe and effective for actinic keratosis (AK), according to a recent Taiwan phase III trial.

The rate of overall complete AK clearance was nonsignificantly greater in the SR-T100 gel (n=76; mean age 76.6±88 years; 67.1 percent male) than in the vehicle control group (n=36; mean age 76.7±9.2 years; 61.1 percent male; 32.4 percent vs 17.1 percent; p=0.111). The odds of overall clearance were likewise nonsignificantly better in the SR-T100 group (odds ratio, 2.14; 95 percent CI, 0.74-6.17).

In comparison, the rate of complete clearance was significantly better when analysis was confined to the arm/chest (52.6 percent vs 0 percent; p=0.010).

The SR-T100 gel appeared to be significantly better than the vehicle control when it came to the secondary outcome of partial clearance. There were more patients in the SR-T100 vs control group who experienced 75 percent clearance (71.8 percent vs 37.1 percent; p<0.001).

Partial clearance of ≥80 percent, ≥85 percent, ≥90 percent and ≥95 percent were also significantly more common in the SR-T100 vs vehicle control treatments.

The rate of at least one adverse event (55.3 percent vs 51.4 percent) and serious adverse events (13.2 percent vs 13.5 percent) were comparable between the two treatments. Local skin reactions such as erythema (43.4 percent vs 18.9 percent), burning/stinging (36.8 percent vs 8.1 percent) and erosion (34.2 percent vs 5.4 percent) were all more common in the SR-T100 group, and severity of these reactions were correlated positively with degree of treatment response.

“SR-T100, because of its favourable local skin reaction profile compared to other currently available treatment option[s], is a better topical agent for long-term field therapy for AK,” said researchers.

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Most Read Articles
Tristan Manalac, 5 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
3 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.