Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.

Topical fluorouracil better than imiquimod in preventing keratinocyte carcinoma

11 Apr 2019

Overall, 5-fluorouracil is more effective than imiquimod in reducing the risk of keratinocyte carcinoma, but there are no differences in the short- or long-term risk of subsequent site-specific keratinocyte carcinoma in a real-world practice setting, according to a new study.

Compared with imiquimod, 5-fluorouracil correlated with a statistically significant lower risk of any keratinocyte carcinoma (adjusted hazard ratio [aHR], 0.86; 95 percent CI, 0.76–0.97). However, no significant differences were seen in risk by tumour subtype (for squamous cell carcinoma: aHR, 0.89; 0.74–1.07; for basal cell carcinoma: aHR, 0.87; 0.74–1.03) or site-specific keratinocyte carcinoma (aHR, 0.96; 0.81–1.14).

In addition, there were no significant between-group differences found in 2- or 5-year cumulative risk of keratinocyte carcinoma among patients.

In a previous study, results showed that 5-fluorouracil was significantly more effective than imiquimod in the short-term, but not long-term, prevention of subsequent actinic keratosis. [J Am Acad Dermatol 2018;78:710-716]

In the current study, the authors identified 5,700 patients who filled prescriptions for 5-fluorouracil or imiquimod for the treatment of actinic keratosis in 2007 to compare the effectiveness of the two agents in preventing keratinocyte carcinoma in a real-world practice setting.

They also calculated 2- and 5-year cumulative risk differences for subsequent keratinocyte carcinoma overall and in field-treated areas using an intention-to-treat analysis controlling for potential confounding variables.

“Generalizability to other practice settings may be limited,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.