Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.

Topical fluorouracil better than imiquimod in preventing keratinocyte carcinoma

11 Apr 2019

Overall, 5-fluorouracil is more effective than imiquimod in reducing the risk of keratinocyte carcinoma, but there are no differences in the short- or long-term risk of subsequent site-specific keratinocyte carcinoma in a real-world practice setting, according to a new study.

Compared with imiquimod, 5-fluorouracil correlated with a statistically significant lower risk of any keratinocyte carcinoma (adjusted hazard ratio [aHR], 0.86; 95 percent CI, 0.76–0.97). However, no significant differences were seen in risk by tumour subtype (for squamous cell carcinoma: aHR, 0.89; 0.74–1.07; for basal cell carcinoma: aHR, 0.87; 0.74–1.03) or site-specific keratinocyte carcinoma (aHR, 0.96; 0.81–1.14).

In addition, there were no significant between-group differences found in 2- or 5-year cumulative risk of keratinocyte carcinoma among patients.

In a previous study, results showed that 5-fluorouracil was significantly more effective than imiquimod in the short-term, but not long-term, prevention of subsequent actinic keratosis. [J Am Acad Dermatol 2018;78:710-716]

In the current study, the authors identified 5,700 patients who filled prescriptions for 5-fluorouracil or imiquimod for the treatment of actinic keratosis in 2007 to compare the effectiveness of the two agents in preventing keratinocyte carcinoma in a real-world practice setting.

They also calculated 2- and 5-year cumulative risk differences for subsequent keratinocyte carcinoma overall and in field-treated areas using an intention-to-treat analysis controlling for potential confounding variables.

“Generalizability to other practice settings may be limited,” the authors said.

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Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.