Most Read Articles
Jairia Dela Cruz, 14 Jan 2019
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
08 Jan 2019
Treatment with spironolactone has shown consistent, albeit modest, clinical effectiveness in older patients with heart failure with reduced ejection fraction (HFrEF) regardless of renal eligibility criteria used, a recent study has shown.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Topical 5-fluorouracil, interferon alfa-2b eye drops both effective, safe for OSSN

15 Dec 2018

Topical 5-fluorouracil 1% (5FU) is as good as interferon alfa-2b 1 MIU/mL (IFN) eye drops in the primary treatment of ocular surface squamous neoplasia (OSSN), with both modalities leading to high tumour resolution and low recurrence rates, a recent study has shown.

Researchers examined the medical records of 54 patients who received 5FU and 48 patients who received IFN as primary therapy for OSSN. Primary outcome measures included the frequency of clinical resolution and time to OSSN recurrence. Secondary outcome was the frequency of side effects with each therapy.

The mean age of the cohort was 68 years, and a greater proportion of Hispanics were treated with 5FU. In a univariable analysis, the frequency of OSSN resolution was higher with 5FU than with IFN (96.3 percent vs 81.3 percent; p=0.01). However, multivariable analysis showed that treatment modality was not a significant predictor of resolution.

Among patients with resolved OSSN, mean time to resolution was similar between 5FU and IFN (mean 6.6 vs 5.5 months; p=0.17). Likewise, there was no significant difference in the number of resolved lesions that recurred (6 of 52 eyes vs 2 of 39 eyes, respectively; p=0.46), with Kaplan Meier survival curves of OSSN recurrence being similar between the two teatment groups (log rank=0.16).

Recurrence rates at 1 year were 11.4 percent with 5FU and 4.5 percent with IFN. Adverse events such as eyelid oedema (p=0.04) and tearing (p=0.02) were more significant with 5FU.

The present data suggest that both topical 5FU and IFN eye drops are effective treatment options for OSSN.

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Most Read Articles
Jairia Dela Cruz, 14 Jan 2019
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
08 Jan 2019
Treatment with spironolactone has shown consistent, albeit modest, clinical effectiveness in older patients with heart failure with reduced ejection fraction (HFrEF) regardless of renal eligibility criteria used, a recent study has shown.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.