Most Read Articles
Pearl Toh, 20 Jul 2018
Women with pre-eclampsia or gestational hypertension during their first pregnancy had an increased risk of developing chronic hypertension, type 2 diabetes (T2D), and hypercholesterolaemia than those who were normotensive during pregnancy, according to a study. The risk persisted for several decades later, signalling these hypertensive disorders of pregnancy (HDP) as red flags for cardiovascular (CV) health for life.
Roshini Claire Anthony, 30 Jul 2018

Canagliflozin may provide a renoprotective effect in individuals with type 2 diabetes (T2D) and a history of cardiovascular disease (CVD), according to results from the CANVAS* Program.

Stephen Padilla, 31 Jul 2018
Patients with type 2 diabetes (T2D) treated with sulphonylureas as second-line drugs are at an increased risk of myocardial infarction (MI), all-cause mortality and severe hypoglycaemia compared with those who remained on metformin monotherapy, a recent study has found.
22 Jul 2018
There appears to be a nonlinear relationship between total oestradiol and free oestradiol and all-cause mortality among older men, according to data from the Three-City cohort study. Specifically, the association is stronger for cardiovascular disease mortality and nonexistent for cancer mortality.

Tooth loss may signify T2D risk

Audrey Abella
25 Apr 2018

Tooth loss or missing teeth due to decay or periodontal disease may suggest an increased risk of type 2 diabetes (T2D), according to a study presented at ENDO 2018 held in Chicago, Illinois, US.

 

Dental caries and periodontal disease are hallmarks of poor dental health which, if left untreated, may lead to tooth loss, said lead author Dr Raynald Samoa from the Department of Diabetes, Endocrinology & Metabolism at the City of Hope National Medical Center in Duarte, California, US. “Our results showed a progressive positive relationship between worsening glucose tolerance and number of missing teeth.”

 

Samoa and colleagues established the link between dental health and glucose tolerance by reviewing records of 9,670 adults (>20 years) and evaluating the following parameters: body mass index (BMI) and glucose tolerance states by fasting plasma glucose, 2-hour post-challenge plasma glucose, HbA1c, established T2D, and treatment with oral agents or insulin. Participants were divided into three groups according to glucose tolerance (GT): normal (NGT), abnormal (AGT), or T2D. Dental records were documented to determine the number of decayed or missing teeth caused by caries or periodontal disease and periodontal status. [ENDO 2018, abstract MON-118]

 

The incidence of missing teeth was highest among those with reduced glucose tolerance (45.57 percent, 67.61 percent, and 82.87 percent in the NGT, AGT, and T2D groups, respectively; p<0.000001), which remained significant even after adjusting for covariates* (p=0.000019).

 

There was also a significant difference in the average number of missing teeth among the three groups (2.26, 4.41, and 6.80 in the NGT, AGT, and T2D groups, respectively; p<0.000001).

 

Excluding gender, all other covariates had a significant impact on the number of missing teeth (p=0.000002 for BMI, p<0.000001 for other covariates).

 

“[Our findings suggest that] the health of your teeth may be a sign of your risk for [T2D, which] is estimated to increase the risk of periodontitis by two- to threefold,” said Samoa. Although a causal relationship cannot be inferred from this cross-sectional study, it demonstrates that poor dental outcome can be observed before the onset of overt diabetes,” he added.

 

These results support evidence linking severe periodontitis to a higher risk of poor glycaemic control, said Samoa. Given the growing incidence of T2D, a dental examination could be an essential tool that could help identify patients at risk for developing T2D, he added.

 

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 20 Jul 2018
Women with pre-eclampsia or gestational hypertension during their first pregnancy had an increased risk of developing chronic hypertension, type 2 diabetes (T2D), and hypercholesterolaemia than those who were normotensive during pregnancy, according to a study. The risk persisted for several decades later, signalling these hypertensive disorders of pregnancy (HDP) as red flags for cardiovascular (CV) health for life.
Roshini Claire Anthony, 30 Jul 2018

Canagliflozin may provide a renoprotective effect in individuals with type 2 diabetes (T2D) and a history of cardiovascular disease (CVD), according to results from the CANVAS* Program.

Stephen Padilla, 31 Jul 2018
Patients with type 2 diabetes (T2D) treated with sulphonylureas as second-line drugs are at an increased risk of myocardial infarction (MI), all-cause mortality and severe hypoglycaemia compared with those who remained on metformin monotherapy, a recent study has found.
22 Jul 2018
There appears to be a nonlinear relationship between total oestradiol and free oestradiol and all-cause mortality among older men, according to data from the Three-City cohort study. Specifically, the association is stronger for cardiovascular disease mortality and nonexistent for cancer mortality.