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Tolterodine-pilocarpine combo eases dry mouth in patients with overactive bladder

03 Sep 2019

The combination of tolterodine 2 mg and pilocarpine 9 mg relieves dry mouth in patients with overactive bladder while maintaining anticholinergic efficacy similar to that of tolterodine alone, a study has shown.

From baseline to 12 weeks, the mean change in the number of daily micturitions was –1.49 in the combination group and –1.74 in the tolterodine monotherapy group, with a mean difference of –0.26 (95 percent CI, –0.79 to 0.27), confirming noninferiority.

The combination group also had a lower incidence of dry mouth at 12 weeks than the tolterodine monotherapy group (30.0 percent vs 42.9 percent; p=0.009). Each group showed improvements in all secondary and other efficacy outcomes associated with overactive bladder symptoms, with no significant between-group differences at 12 weeks.

In addition, the combination group had significantly lower scores on the total xerostomia inventory and the visual analogue scale for dry mouth than the tolterodine monotherapy group.

Patients with overactive bladder symptoms were enrolled in this multicentre, randomized, double-blind, parallel, active control study. They were randomly assigned to receive either the combination or the 2-mg tolterodine twice daily for 12 weeks. All patients initiated the combination for 12 weeks after the double-blind period was completed.

The change from baseline in the mean number of daily micturitions and cumulative incidence of dry mouth at the end of 12 weeks were the primary endpoints. Secondary endpoints included other overactive bladder symptoms, total xerostomia inventory score, and results of a visual analogue scale for dry mouth at the end of 12 and 24 weeks.

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Most Read Articles
Jairia Dela Cruz, 12 Dec 2019
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).
Rachel Soon, 18 Feb 2020

Pharmaceutical industry representatives highlighted lesser-known career opportunities for licensed pharmacists at the recent Pharmaceutical Industries Pharmacists Insights 3.0 (PIPI 3.0) symposium in Petaling Jaya.

Elvira Manzano, 12 Nov 2019
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Elaine Soliven, 20 Feb 2020
The administration of either low- or high-dose oxytocin does not impact time from induction of labour to delivery in lean and obese women, according to a study presented at SMFM 2020.