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Pearl Toh, 2 days ago
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Tofacitinib trumps vedolizumab for short-term efficacy in ulcerative colitis

30 Jan 2020

Short-term efficacy appears to be higher with tofacitinib (TOF) than with vedolizumab (VDZ) in the treatment of patients with ulcerative colitis (UC), regardless of disease severity and previous biologics use, a recent study has shown.

This retrospective single-centre observation study included UC patients who initiated TOF (n=38) or VDZ (n=28) from May 2018 to May 2019. Short-term efficacy was evaluated by remission rate, defined as a partial Mayo score (pMayo) of 1 point, and response rate, defined as a pMayo 1 point or a decrease of 3 points, at 2 and 6 weeks after treatment initiation.

The authors also examined the clinical background factors contributing to the efficacy at 6 weeks and evaluated the side effects in the mean observation period (TOF: 133.6 days; VDZ: 74.6 days).

Clinical background factors were not significantly different between the TOF and VDZ groups in terms of clinical duration (10.7 vs 7.9 years), relapse-remission type (71.1 percent vs 64.3 percent) and all colitis type (63.2 percent vs 60.7 percent).

However, the TOF group had more severe UC (average pMAYO, 5.7 vs 4.0 points; p=0.002; average endoscopic Mayo score [eMayo], 2.58 vs 1.82; p=0.002; average UC endoscopic index of severity, 4.34 vs 2.71; p=0.001) and fewer bio-naive cases (23.7 percent vs 50.0 percent; p=0.027).

The remission rates were comparable at weeks 2 (23.7 percent vs 28.5 percent; p=0.654) and 6 (39.4 percent vs 32.1 percent; p=0.611), while the response rates were higher for the TOF group at weeks 2 (50.0 percent vs 35.7 percent; p=0.248) and 6 (63.2 percent vs 35.7 percent; p=0.027).

No serious side effects were reported. None of the patients in both groups discontinued treatment due to side effects.

“In the near future, further head-to-head study is required to extend these findings and determine the appropriate therapeutic options in terms of the mid- to long-term efficacy and safety,” the authors said.

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Most Read Articles
Pearl Toh, 2 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
5 days ago
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.