Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Tofacitinib trumps vedolizumab for short-term efficacy in ulcerative colitis

30 Jan 2020

Short-term efficacy appears to be higher with tofacitinib (TOF) than with vedolizumab (VDZ) in the treatment of patients with ulcerative colitis (UC), regardless of disease severity and previous biologics use, a recent study has shown.

This retrospective single-centre observation study included UC patients who initiated TOF (n=38) or VDZ (n=28) from May 2018 to May 2019. Short-term efficacy was evaluated by remission rate, defined as a partial Mayo score (pMayo) of 1 point, and response rate, defined as a pMayo 1 point or a decrease of 3 points, at 2 and 6 weeks after treatment initiation.

The authors also examined the clinical background factors contributing to the efficacy at 6 weeks and evaluated the side effects in the mean observation period (TOF: 133.6 days; VDZ: 74.6 days).

Clinical background factors were not significantly different between the TOF and VDZ groups in terms of clinical duration (10.7 vs 7.9 years), relapse-remission type (71.1 percent vs 64.3 percent) and all colitis type (63.2 percent vs 60.7 percent).

However, the TOF group had more severe UC (average pMAYO, 5.7 vs 4.0 points; p=0.002; average endoscopic Mayo score [eMayo], 2.58 vs 1.82; p=0.002; average UC endoscopic index of severity, 4.34 vs 2.71; p=0.001) and fewer bio-naive cases (23.7 percent vs 50.0 percent; p=0.027).

The remission rates were comparable at weeks 2 (23.7 percent vs 28.5 percent; p=0.654) and 6 (39.4 percent vs 32.1 percent; p=0.611), while the response rates were higher for the TOF group at weeks 2 (50.0 percent vs 35.7 percent; p=0.248) and 6 (63.2 percent vs 35.7 percent; p=0.027).

No serious side effects were reported. None of the patients in both groups discontinued treatment due to side effects.

“In the near future, further head-to-head study is required to extend these findings and determine the appropriate therapeutic options in terms of the mid- to long-term efficacy and safety,” the authors said.

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Editor's Recommendations
Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.