Most Read Articles
6 days ago
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Roshini Claire Anthony, 18 hours ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 3 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
6 days ago
Greater home blood pressure (BP) variability, particularly in home systolic (S)BP, correlates with higher carotid, aortic and peripheral but not coronary atherosclerosis burdens independent of the mean home BP, suggests a recent study.

Tofacitinib improves hair regrowth in alopaecia areata

27 Jun 2018

JAK inhibitor tofacitinib appear to have therapeutic potential to halt hair loss in patients with alopaecia areata, a recent study has shown.

The open-label pilot study included 12 moderate-to-severe alopaecia areata patients, of whom eight achieved the primary efficacy endpoint of 50-percent hair regrowth from baseline. Tofacitinib therapy duration ranged from 6–18 months. The mean time to reach the primary endpoint was 32 weeks.

Of the five patients with either alopaecia universalis or alopaecia totalis, four participants achieved 50-percent har regrowth.

Participants who reached the primary efficacy endpoint during the first 6–18 months were followed for an additional 6 months off-treatment. Six patients showed variable hair shedding after treatment conclusion, two of whom showed the initial signs of shedding within 3–4 weeks. Excellent durability of treatment response was reported in three participants.

Mean baseline scores in the Dermatology Life Quality Index was 6.5±5 points, which dropped to 5.2±6.7 at 3 months and to 6±6.9 points after the 6-month treatment regimen.

In terms of treatment safety, the most common adverse event was upper respiratory infections of any grade, reported in 91.6 percent (n=11) of the patients. This was followed by increased bowel movement frequency (33.3 percent; n=4) and blood on urinalysis (33.3 percent; n=4). One patient with a history of hypertension discontinued treatment due to hypertensive urgency.

For the study, treatment outcomes were measured using the Severity in Alopecia Tool score. Hair regrowth as a continuous variable was evaluated using Canfield photography.

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Most Read Articles
6 days ago
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Roshini Claire Anthony, 18 hours ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 3 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
6 days ago
Greater home blood pressure (BP) variability, particularly in home systolic (S)BP, correlates with higher carotid, aortic and peripheral but not coronary atherosclerosis burdens independent of the mean home BP, suggests a recent study.