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29 Nov 2019
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Tocilizumab induces remission in polymyalgia rheumatica even without glucocorticoids

17 Nov 2019

Monotherapy with tocilizumab (TCZ) shows good tolerability profile and results in remission in most patients with polymyalgia rheumatica (PMR) despite the absence of glucocorticoids, according to the 2-year results of a single-centre, open‐label pilot study.

A total of 13 patients (average age, 70.1 years; average PMR duration, 4.0 months) received TCZ (8 mg/kg) at fortnightly intervals for the first 2 months, then monthly over the next 10 months. These patients were observed for another year without any treatment.

The primary endpoint of remission occurred in four patients at week 12, yielding a rate of 31 percent. There were four patients who discontinued treatment: two due to adverse events and another two due to lack of effect.

At week 52, the nine remaining patients who completed 1 year of treatment were all in remission. All but one patient completed the follow-up at year 2, of which seven maintained remission.

A systemic inflammatory disease in the elderly of unknown aetiology, PMR is treated with glucocorticoids, although the drug is associated with frequent occurrences of various adverse events, researchers noted.

TCZ, on the other hand, is a major candidate therapeutic strategy for PMR in older patients with comorbidities that inhibit the use of glucocorticoids, they said, adding that this is despite several issues that might limit its use, including the cost and risks of infection and dyslipidaemia.

The researchers underscored a need to conduct further clinical studies to address several outstanding questions about TCZ treatment for PMR, including the frequency of infusions, treatment period and possibility of the use of subcutaneous injections.

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Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
3 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Pearl Toh, 3 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
3 days ago
While douching is not associated with the risk of ovarian cancer, the combination of talc and commercially available douches contributes to a modest increase in the risk of epithelial ovarian cancer beyond that conferred by talc use alone, as shown in a recent study.